TLR4/MyD88/NF-κB信号通路在RA中的作用及中药干预研究进展  

Role of TLR4/MyD88/NF-κB Signaling Pathway in RA and Research Progress in Chinese Medicinal Intervention

作　　者：王瑞杰 王钢 张丽 WANG Ruijie;WANG Gang;ZHANG Li(Gansu University of Chinese Medicine,Lanzhou 730000,China;Baiyin Integrated Hospital of Traditional Chinese and Western Medicine,Baiyin 730900,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]白银市中西医结合医院,甘肃白银730900 [3]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中医药信息》2023年第8期84-89,共6页Information on Traditional Chinese Medicine

基　　金：甘肃省青年科技基金计划项目(22JR5RD1024);甘肃省中医药科研课题项目(GZKP-2022-45)。

摘　　要：TLR4/MyD88/NF-κB作为机体炎症的重要信号通路,参与许多疾病的发生与调控过程。类风湿关节炎(RA)是一种慢性自身免疫性疾病,发病机制尚不完全明确,但诸多研究表明,TLRs、NF-κB等炎症信号通路在RA的发生、发展中起着重要的作用,另有研究表明中药可通过影响TLRs、MyD88、NF-κB等信号通路起到调节免疫、调节细胞因子的作用。因此,拟通过分析TLR4/MyD88/NF-κB信号通路在RA发生、发展中的作用,初步探讨中医药通过TLR4/MyD88/NF-κB信号通路治疗RA的研究现状及作用机理,为RA的治疗提供更多的治疗途径。As an important signaling pathway for inflammation,TLR4/MyD88/NF-κB participates in the occurrence and regulation of many diseases.Rheumatoid arthritis(RA)is a chronic autoimmune disease,the pathogenesis of RA is not completely clear,but many studies have shown that TLRs and NF-κB inflammatory signaling pathways play an important role in the occurrence and development of RA.Other studies have shown that Chinese medicinal can affect TLRs,MyD88 and NF-κB signaling pathways,and play a role in regulating immunity and cytokines.Therefore,this study intends to analyze TLR4/MyD88/NF-κB signaling pathway in the occurrence and development of RA,and the research status and mechanism were preliminarily studied on the effect of Chinese medicinal on TLR4/MyD88/NF-κB signaling pathway in treatment of RA,so as to provide more therapeutic approaches for the treatment of RA.

关 键 词：中药 TLR4/MyD88/NF-κB信号通路 类风湿关节炎 

分 类 号：R259[医药卫生—中西医结合]