骨质疏松受体基因研究方向  

Research direction of osteoporosis receptor genes

作　　者：张萌萌 尹纪伟 高远 ZHANG Mengmeng;YIN Jiwei;GAO Yuan(Chinese Journal of Osteoporosis,Beijing 100102;Jilin FAW General Hospital,Changchun 130013,China)

机构地区：[1]《中国骨质疏松杂志》社,北京100102 [2]吉林省一汽总医院,吉林长春130013

出　　处：《中国骨质疏松杂志》2023年第7期982-986,共5页Chinese Journal of Osteoporosis

摘　　要：骨质疏松症(osteoporosis)是一种以骨量低下、骨组织微结构损坏,导致骨脆性增加,易发生骨折为特征的全身性骨病。骨质疏松是多因素、多基因疾病,是遗传和环境因素交互作用的结果。笔者论述了降钙素受体基因、甲状旁腺素受体基因、雌激素受体基因、肿瘤坏死因子基因、胰岛素样生长因子1受体基因、骨保护素基因、转化生长因子基因、维生素D受体基因、Ⅰ型胶原蛋白基因的生物学特征及其与骨密度、骨质疏松、骨质疏松性骨折的关联,为骨质疏松的发病机制、预防治疗、新药开发研究提供分子生物学依据。Osteoporosis is a systemic bone disease characterized by low bone mass,damage to bone tissue microstructure,increased bone fragility,and susceptibility to fractures.Osteoporosis is a multifactorial and polygenic disease,which is the result of the interaction between genetic and environmental factors.This article discusses the biological characteristics of Calcitonin receptor gene,parathyroid hormone receptor gene,estrogen receptor gene,tumor necrosis factor gene,insulin-like growth factor 1 receptor gene,osteoprotegerin gene,transforming growth factor gene,vitamin D receptor gene,type I collagen gene and their association with bone density,osteoporosis,and osteoporotic fractures,which are the pathogenesis,prevention and treatment of osteoporosis The development and research of new drugs provide molecular biology basis.

关 键 词：降钙素受体基因 甲状旁腺素受体基因 雌激素受体基因 肿瘤坏死因子基因 胰岛素样生长因子1受体基因 骨保护素基因 转化生长因子基因 维生素D受体基因 Ⅰ型胶原蛋白基因 骨质疏松 

分 类 号：R589.5[医药卫生—内分泌]