从“肾-骨-髓-脑”理论探讨外泌体与原发性骨质疏松症的关系  

Study of the relationship between exosomes and primary osteoporosis based on the kidney- bone-marrow-brain theory

作　　者：王庆谚[1] 金颖[1] 李佳[1] 郑洪新[1] 贾连群[1,2] 杨关林[1,2] WANG Qingyan;JIN Ying;LI Jia;ZHENG Hongxin;JIA Lianqun;YANG Guanlin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Center of Traditional Chinese Medicine Innovation Engineering Technology,Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学中医药创新工程技术中心脏象理论及应用教育部重点实验室,辽宁沈阳110847

出　　处：《中国骨质疏松杂志》2023年第7期1043-1046,1055,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金青年科学基金(82004229);中国博士后科学基金面上资助“地区专项支持计划”(2021MD703844);中国博士后科学基金特别资助(站中)(2022T150285);辽宁省教育厅重点攻关项目(L202061);辽宁省教育厅青年科技人才“育苗”项目(L202024)。

摘　　要：原发性骨质疏松症(primary osteoporosis, POP)是我国亟待解决的公共健康问题。“肾-骨-髓-脑”系统是中医理论体系的重要组成部分,肾精充盛,则髓化生充足,脑得髓充则髓海清明,骨得髓养而健壮有力,构成了“肾-骨-髓-脑”的系统关联,是防治POP的重要理论依据。该文旨在以“肾-骨-髓-脑”系统理论为基础,从现代分子生物学角度探讨“肾-骨-髓-脑”系统与外泌体之间的关系,为POP的临床防治提供新思路。Primary osteoporosis(POP)is an urgent public health problem to be solved in China.The kidney-bone-marrow-brain system is an important part in the traditional Chinese medicine(TCM)theoretical system.Full of the kidney essence,sufficient of the marrow metaplasia,clear in brain marrow sea,and strong of bone myeloid constitute the connection of kidney-bone-bone-brain system.It is an important theoretical basis for POP prevention and treatment.This paper aims to explore the relationship between the kidney-bone-marrow-brain system and exosomes from the perspective of the kidney-bone-marrow-brain system theory,so as to provide new ideas for the clinical prevention and treatment of POP.

关 键 词：原发性骨质疏松症 肾 精 脑 外泌体 

分 类 号：R589.5[医药卫生—内分泌] R223.1[医药卫生—内科学]