生物钟基因Bmal1与骨重塑的研究  

Research progress on circadian clock gene bmal1 and bone remodeling

作　　者：谭国志 黄佳纯 蔡绍铭 钟巍 刘志文 黄宏兴 张志海 TAN Guozhi;HUANG Jiachun;CAI Shaoming;ZHONG Wei;LIU Zhiwen;HUANG Hongxing;ZHANG Zhihai(The Third Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510378,China)

机构地区：[1]广州中医药大学第三临床医学院,广东广州510405 [2]广州中医药大学第三附属医院,广东广州510378

出　　处：《中国骨质疏松杂志》2023年第7期1074-1078,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(81973886);广州中医药大学“双一流”与高水平大学学科协同创新团队重点项目(2021XK21);广东省研究生教育创新计划项目(2022XSLT013);沃华科研基金资助项目(BYPDF2231206);骨质疏松和骨矿盐疾病中青年医生优才培养计划暨白求恩·石药骨质疏松科研基金项目(GX2021C02)。

摘　　要：骨重塑是修复骨结构的微损伤和替换老化骨组织的过程,对于保持骨骼的稳定性和完整性至关重要。研究发现骨重塑的循环标志物呈现出昼夜节律性变化,骨稳态也受到昼夜节律的影响,昼夜节律紊乱会导致骨质流失。Bmal1基因是生物钟的核心组成部分,在骨代谢细胞中发挥着重要的作用,Bmal1的异常表达将会导致骨重塑失衡。本文将对Bmal1在骨重塑中的作用进行综述,叙述其在成骨细胞、破骨细胞以及骨髓间充质干细胞的作用。旨在深入探索生物钟基因Bmal1与骨重塑的关系,以期为未来治疗骨重塑相关疾病提供新的思路。Bone remodeling is the process of repairing microdamage to bone structures and replacing aging bone tissue,which is essential for maintaining the stability and integrity of bones.Studies have found that the circulatory markers of bone remodeling show circadian rhythmic changes,and bone homeostasis is also affected by circadian rhythm,which can lead to bone loss.The Bmal1 gene is a core component of the biological clock and plays an important role in bone metabolic cells,and abnormal expression of Bmal1 will lead to imbalance in bone remodeling.The role of Bmal1 in bone remodeling will be reviewed here,describing its role in osteoblasts,osteoclasts,and bone marrow mesenchymal stem cells.Further exploration of the relationship between circadian clock gene Bmal1 and bone remodeling can provide new ideas for the treatment of bone remodeling related diseases in the future.

关 键 词：Bmal1基因 骨重塑 骨髓间充质干细胞 成骨细胞 破骨细胞 

分 类 号：R681[医药卫生—骨科学]