不典型川崎病患儿Th17细胞因子水平与冠状动脉病变的关系研究  

Relationship between Th17 cytokines and coronary artery lesion in children with atypical Kawasaki disease

作　　者：翁艳 魏亚新 WENG Yan;WEI Yaxin(Authors'address:Department of Pediatrics,Huzhou First Hospital,Huzhou 313000,China)

机构地区：[1]湖州市第一医院儿科,313000

出　　处：《心电与循环》2023年第4期381-384,共4页Journal of Electrocardiology and Circulation

摘　　要：目的 分析不典型川崎病(KD)患儿辅助性T细胞17(Th17)细胞因子水平与冠状动脉(下称冠脉)病变的关系。方法 选择2015年1月至2020年12月湖州市第一医院收治的102例不典型KD患儿作为观察组,另择同期在本院门诊行健康体检的98名儿童作为对照组。比较两组对象血清白介素-17A(IL-17A)水平,比较观察组中冠脉病变亚组和非冠脉病变亚组患儿年龄、体重、发热时间、白细胞、血小板、血红蛋白、血沉、血钠、血清C反应蛋白(CRP)及IL-17A水平。采用多因素logistic回归分析血清IL-17A水平与冠脉病变的关系。结果 观察组患儿血清IL-17A水平高于对照组(P<0.05);观察组患儿冠脉病变26例(25.49%),冠脉病变亚组白细胞、血小板、血沉、CRP、IL-17A水平均高于无冠脉病变亚组(均P<0.01);白细胞、血小板、血沉、CRP、IL-17A水平均是不典型KD患儿冠脉病变的危险因素(OR=2.415、2.782、2.816、3.649、4.493,均P<0.05)。结论 Th17细胞因子IL-17A水平升高的不典型KD患儿发生冠脉病变的风险增高。Objective To analyze the relationship between Th17 cytokines and coronary artery lesions(CAL)in children with atypical Kawasaki disease(KD).Methods One hundred and two children with atypical KD admitted to Huzhou First Hospital from January 2015 to December 2020 were selected as observation group,and 98 children who underwent physical examination at the same time were selected as control group.Serum interleukin-17A(IL-17A)were compared between the two groups.The age,weight,fever time,white blood cells,platelets,hemoglobin,erythrocyte sedimentation rate,blood sodium,serum C-reactive protein(CRP)and IL-17A were compared between patients with and without CAL in the observation group.Multiple logistic regression was used to analyze the relationship between serum IL-17A level and CAL.Results Serum IL-17A was significantly higher in the observation group than in the control group(P<0.05).CAL were detected in 26 cases in the observation group(25.49%).In the observation group,white blood cells,platelets,erythrocyte sedimentation rate,CRP and IL-17A were significantly higher in children with CAL than in children without CAL(all P<0.01).Leukocyte,platelet,erythrocyte sedimentation rate,CRP and IL-17A water were the risk factors of CAL in children with atypical KD(OR=2.415,2.782,2.816,3.649,4.493,all P<0.05).Conclusion The risk of CAL increases in children with atypical KD and increased Th17 cytokine.

关 键 词：不典型川崎病 辅助性T细胞17 白介素-17A 冠脉病变 

分 类 号：R725.4[医药卫生—儿科]