钾离子通道在低氧性肺动脉高压中的作用及药物干预研究进展  

Research progress on the role of potassium channels and drug intervention in hypoxic pulmonary hypertension

作　　者：张朝霞[1,2] 南星梅 李占强[1] 芦殿香[1,3] ZHANG Zhaoxia;NAN Xingmei;LI Zhanqiang;LU Dianxiang(Research Center for High Altitude Medicine,Qinghai University,Key Laboratory of High Altitude Medicine,Ministry of Education,Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province,Qinghai-Utah Joint Research Key Lab for High Altitude Medicine,Xining 810001,China;Qinghai Health Insitutu of Sciences;Central Laboratory,Clinical Medical College&Affiliated Hospital of Chengdu University)

机构地区：[1]青海大学高原医学研究中心,高原医学教育部重点实验室,青海省高原医学应用基础重点实验室,青海-犹他高原医学联合重点实验室,810001 [2]青海卫生职业技术学院 [3]成都大学附属医院中心实验室

出　　处：《天津医药》2023年第8期892-896,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81860768,82060786,32060088);青海省科技厅自然科学基金面上项目(2021-ZJ-907);高原医学教育部重点实验室-青海省高原医学应用基础重点实验室(青海-犹他高原医学联合重点实验室)开放课题资助项目(2022-KF-01);青海省“昆仑英才·教学名师”人才项目;青海省“昆仑英才·高端创业人才”项目。

摘　　要：钾离子(K^(+))通道是位于细胞膜上的一种跨膜蛋白,血管平滑肌细胞K^(+)通道通过膜电位在血管张力、细胞兴奋性和细胞增殖等方面发挥重要调控作用。肺动脉平滑肌细胞K^(+)通道功能障碍与低氧性肺动脉高压(HPH)的病理进程密切相关,K^(+)通道有望成为HPH的治疗靶点。对肺动脉平滑肌细胞K^(+)通道的种类以及在HPH中的研究进展、相关干预药物进行综述,旨在为HPH的发病机制研究和药物研发提供新思路。Potassium ion(K^(+))channel is a transmembrane protein located on cell membrane.The K^(+)channels of vascular smooth muscle cells play an important role in regulating vascular tension,cell excitability and proliferation through membrane potential.The dysfunction of K^(+)channels in pulmonary artery smooth muscle cells(PASMCs)is closely related to the pathological process of hypoxic pulmonary hypertension(HPH),and K^(+)channels are expected to become the therapeutic target of HPH.In this artical,types of K^(+)channels in PASMCs,the research progress of K^(+)channels in HPH and drugs that interfere with HPH were reviewed,in order to provide new ideas for the pathogenesis research and drug development of HPH.

关 键 词：肺动脉高压 低氧 钾通道 肌细胞 平滑肌 低氧性肺血管收缩 低氧性肺血管重构 药物干预 

分 类 号：R544.16[医药卫生—心血管疾病]