Biosensing with free space whispering gallery mode microlasers  

作　　者：ANGELA CAPOCEFALO SILVIA GENTILINI LORENZO BAROLO PAOLA BAIOCCO CLAUDIO CONTI NEDA GHOFRANIHA 

机构地区：[1]Istituto dei Sistemi Complessi-CNR,UOS UniversitàLa Sapienza,I-00185 Rome,Italy [2]Dipartimento di Scienze Biochimiche A.Rossi Fanelli,UniversitàLa Sapienza,I-00185 Rome,Italy [3]Dipartimento di Fisica,UniversitàLa Sapienza,I-00185 Rome,Italy

出　　处：《Photonics Research》2023年第5期732-741,共10页光子学研究（英文版）

基　　金：Rome Technopole(ECS00000024-Next Generation EU,CUP:B83C22002890005);Regione LAZIO;Lazio-Innova;POR FESR Lazio 2014-2020;European Commission(A0375-2020-36549,CUP:B85F20003340002)。

摘　　要：Highly accurate biosensors for few or single molecule detection play a central role in numerous key fields,such as healthcare and environmental monitoring.In the last decade,laser biosensors have been investigated as proofs of concept,and several technologies have been proposed.We here propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins,down to 400 pg.They have the advantage of working in free space without any need for waveguiding for input excitation or output signal detection.The photonic microsensors can be easily patterned on microscope slides and operate in air and solution.We estimate the limit of detection up to 148 nm/RIU for three different protein dispersions.In addition,the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.

关 键 词：PASSIVE MODE EXCITATION 

分 类 号：TN248[电子电信—物理电子学] TP212.3[自动化与计算机技术—检测技术与自动化装置]