Collagen fiber anisotropy characterization by polarized photoacoustic imaging for just-in-time quantitative evaluation of burn severity  

作　　者：ZHENHUI ZHANG WEI CHEN DANDAN CUI JIE MI GEN MU LIMING NIE SIHUA YANG YUJIAO SHI 

机构地区：[1]MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,South China Normal University,Guangzhou 510631,China [2]Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China [3]School of Medicine,South China University of Technology,Guangzhou 510006,China [4]Research Center of Medical Sciences,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China

出　　处：《Photonics Research》2023年第5期817-828,共12页光子学研究（英文版）

基　　金：National Natural Science Foundation of China(12174125,61805085);Science and Technology Planning Project of Guangdong Province,China(2015B020233016,2018A030310519);Guangzhou Science and Technology Plan Project(201904010321);Science and Technology Program of Guangzhou(2019050001);Basic and Applied Basic Research Foundation of Guangdong Province(2021A1515011874)。

摘　　要：Just-in-time burn severity assessment plays a vital role in burn treatment and care.However,it is still difficult to quantitatively and promptly evaluate burn severity by existing medical imaging methods via initial burn depth measurement since burn wounds are usually dynamically developed.As an elastic skeleton of skin,the degree of conformational changes of collagen fibers caused by overheating can reflect the burn severity in a timelier manner.Herein,the polarized photoacoustic technique(PPAT)for just-in-time quantitative evaluation of burn severity via collagen fiber anisotropy assessment is proposed.First,phantom experiments demonstrate the ability of PPAT for deep imaging in a transport mean free path and accurately quantify changes in microstructural order by thermal damage.Then,the Pearson correlation coefficient of the PPAT in assessing burn severity is shown to be up to 0.95,validated by burn skin samples.The PPAT provides a just-in-time quantitative strategy for burn severity evaluation.

关 键 词：SEVERITY ANISOTROPY POLARIZED 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术] R644[自动化与计算机技术—计算机科学与技术]