高密度脂蛋白量和质在动脉粥样硬化中的临床应用  

Research update on the clinical application of the quantity and quality of high-density lipoprotein in atherosclerosis

作　　者：李江[1] 周允[1] 曹永彤[1] Li Jiang;Zhou Yun;Cao Yongtong(Department of Clinical Laboratory Medicine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院检验科,北京100029

出　　处：《中华检验医学杂志》2023年第7期667-671,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(82272407,82072337);北京市临床重点专科项目(2020年度)。

摘　　要：新的研究证据对于高密度脂蛋白(HDL)具有动脉粥样硬化保护作用的假说提出了质疑。由于HDL颗粒构成的异质性和功能的多样性,对HDL颗粒构成的评估和对HDL功能的检测可以克服单一高密度脂蛋白胆固醇水平测量的不足。该文介绍了HDL量、HDL结构和功能的检测方法及临床应用现状,并提出了未来发展趋势,推测HDL质的评估可能成为未来HDL评估的常规方法。Recent research evidence challenges the hypothesis that high density lipoprotein(HDL)has a protective effect on atherosclerosis.Due to the heterogeneity of HDL particle composition and the diversity of HDL functions,the evaluation of HDL particle composition and the detection of HDL function might overcome the deficiency from the measurement of single high-density lipoprotein cholesterol(HDL-C)level.This review briefly introduced the detection method and clinical application for the"quantity"of HDL,and focused on the current status of clinical application and the future development trend of related detection method for the structure and function of HDL.It is postulated that the evaluation of the"quality"of HDL may become the routine method of HDL detection in the future.

关 键 词：高密度脂蛋白 动脉粥样硬化 心血管疾病 

分 类 号：R543.5[医药卫生—心血管疾病]