新疆塔吉克族、哈萨克族健康成年人脂蛋白(a)水平及相关因素分析  

Analysis of lipoprotein(a) level and related factors in healthy Tajik and Kazak adults in Xinjiang

作　　者：金梦龙 马吾苏木·马木特 合巴丽·沙帕尔买买提 李建新[4] 曹杰[4] 孟凡华 赵倩[1] 李华垠 姬虹宇 贾林·阿布扎力汗 阿布都哈力克·艾盖西 鲁向锋[4] 付真彦[1] Jin Menglong;Mamute Mawusumu;Shapaermaimaiti Hebali;Li Jianxin;Cao Jie;Meng Fanhua;Zhao Qian;Li Huayin;Ji Hongyu;Abuzhalihan Jialin;Aigaixi Abuduhalike;Lu Xiangfeng;Fu Zhenyan(Department of Cardiology and State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Urology,the First People′s Hospital of Kashgar District,Kashgar 844000,China;Disease Control and Prevention Center of Tashkurgan Tajik Autonomous County,Tashkurghan 845250,China;Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100032,China;Department of Cardiology of the Afliated Hospital of Jining Medical University,Jining 272000,China;Health Commission of Tashkurgan Tajik Autonomous County,Tashkurghan 845250,China)

机构地区：[1]新疆医科大学第一附属医院心脏中心、新疆医科大学省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐830000 [2]喀什地区第一人民医院泌尿外科,喀什844000 [3]塔什库尔干塔吉克自治县疾病预防控制中心,塔什库尔干县845250 [4]北京协和医学院、国家心血管病中心、中国医学科学院阜外医院流行病学研究部,北京100032 [5]济宁医学院附属医院心血管内科,济宁272000 [6]塔什库尔干塔吉克自治县卫生健康委员会,塔什库尔干县845250

出　　处：《中华检验医学杂志》2023年第7期697-704,共8页Chinese Journal of Laboratory Medicine

基　　金：自治区科技支疆项目计划(2020E0278);国家重点研发计划(2021YFC2500600,2021YFC2500605);省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2022-XXG3);国家创新研究群体培育项目(XYD2021C002);国家自然科学基金(81970380)。

摘　　要：目的了解我国塔吉克族和哈萨克族健康成年人脂蛋白(a)[Lp(a)]水平的分布情况及相关因素。方法横断面研究。于2021年5—10月和2022年3—6月,分别在新疆塔什库尔干塔吉克自治县和富蕴县收集2637名塔吉克族[男1010人,年龄(40.08±14.74)岁;女1627人,年龄(38.27±12.90)岁]和1911名哈萨克族[男720人,年龄(42.10±12.26)岁,女1191人,年龄(40.30±10.28)岁]健康成年人的血液样本,检测空腹血糖(FBG)、肌酐(Cr)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和Lp(a),描述Lp(a)水平在不同性别和年龄人群中的分布情况,比较塔吉克族和哈萨克族Lp(a)水平,使用多因素线性回归分析两民族Lp(a)水平相关因素。结果塔吉克族人和哈萨克族人Lp(a)水平分布均呈偏态分布,Lp(a)水平范围分别为0.40~1229.40 mg/L和0.62~2108.58 mg/L,Lp(a)水平分别为78.90(38.60,190.20)和103.30(49.57,234.27)mg/L,差异有统计学意义(P<0.001)。塔吉克族男性和女性Lp(a)水平分别为77.45(39.80,187.10)和79.90(38.60,192.30)mg/L,差异无统计学意义(P=0.948);哈萨克族男性和女性Lp(a)水平分别为109.42(50.49,230.38)和99.01(49.11,237.25)mg/L,差异无统计学意义(P=0.578)。将两民族数据合并分析,调整年龄、性别、BMI、吸烟、饮酒、血压、血糖等因素后,Lp(a)水平与LDL-C水平(标准偏回归系数0.136,P<0.001)和民族(标准偏回归系数0.066,P=0.008)相关。结论塔吉克族和哈萨克族健康成年人Lp(a)水平均存在较大的个体差异,哈萨克族Lp(a)水平高于塔吉克族,塔吉克族和哈萨克族不同性别间Lp(a)水平均无差异,LDL-C和民族是Lp(a)水平的独立相关因素。Objective To investigate the distribution and related factors of lipoprotein(a)[Lp(a)]level in healthy Tajik and Kazak adults in China.Methods A cross-sectional study was conducted from May to October 2021 and March to June 2022,and blood samples were collected from 2,637 healthy Tajik adults[1010 men,average age:(40.08±14.74)years;1627 women,average age:(38.27±12.90)years]in Tashkurgan Tajik Autonomous County and 1911 healthy Kazak adults[720 men,average age:(42.10±12.26)years;1191 women,average age:(38.27±12.90)years]in Fuyun County of Xinjiang.Fasting blood glucose(FBG),creatinine(Cr),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and Lp(a)were measured.The distribution of Lp(a)levels in different sex and age groups was compared.The Lp(a)level of Tajik and Kazakh ethnic groups was compared by Mann-WhitneyU test,and correlation factors of Lp(a)level were analyzed by multiple logistic regression.Results The distribution of Lp(a)level in Tajik and Kazak population was skewed.Lp(a)levels of Tajik and Kazak ranged from the lowest 0.40 mg/L and 0.62 mg/L to the highest 1229.40 mg/L and 2108.58 mg/L,respectively,and the median Lp(a)level was 78.90(38.60,190.20)mg/L and 103.30(49.57,234.27)mg/L,respectively.Median Lp(a)level of Kazak was significantly higher than that of Tjik(P<0.001).The median Lp(a)levels of Tajik males and females were similar:77.45(39.80,187.10)mg/L and 79.90(38.60,192.30)mg/L(P=0.948).The median Lp(a)levels of Kazakh males and females were also similar:109.42(50.49,230.38)mg/L and 99.01(49.11,237.25)mg/L,respectively(P=0.578).After pooling the data of Tajik and Kazak and adjusting for age,sex,BMI,smoking,drinking,blood pressure,blood glucose and other factors,Lp(a)level was correlated with ethnic(standard partial regression coefficient 0.066,P=0.008)and LDL-C level(standard partial regression coefficient 0.136,P<0.001).Conclusions Lp(a)level in healthy Tajik and Kazak adults varied greatly among individuals,and Kazak residents had a higher Lp(a)level than

关 键 词：心血管疾病 脂蛋白(A) 塔吉克族 相关因素 

分 类 号：R195[医药卫生—卫生统计学]