益肾清利活络方治疗腹膜透析患者的效果及对残余肾功能、腹膜功能的影响  

Effect of Yishen Qingli Huoluo Prescription on Patients with Peritoneal Dialysis and Its Influence on Residual Renal Function and Peritoneal Function

作　　者：周丽霞 蒋春波[1] 倪道磊[1] 宋欢[1] 任燕[1] ZHOU Lixia;JIANG Chunbo;NI Daolei;SONG Huan;REN Yan(Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China;不详)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215009

出　　处：《中国医学创新》2023年第21期93-98,共6页Medical Innovation of China

基　　金：苏州市科技局项目(SKYXD2022060)。

摘　　要：目的:观察益肾清利活络方治疗腹膜透析(peritoneal dialysis,PD)患者的效果及对残余肾功能、腹膜功能的影响,并探讨其可能作用机制。方法:选择2018年12月—2022年8月在南京中医药大学附属苏州市中医医院肾病科腹透门诊就诊及住院的PD患者共80例,采用随机数字表法分为治疗组与对照组,各40例,两组均进行常规治疗,治疗组在常规治疗的基础上服用益肾清利活络方3个月。对两组患者的治疗结果进行观察对比。结果:治疗组患者治疗总有效率相较于对照组显著提升(P<0.05)。与治疗前比较,治疗组治疗后前白蛋白(PAB)、血白蛋白(ALB)、血红蛋白(Hb)水平均升高,超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平均下降(P<0.05),且与对照组治疗后相比,差异均有统计学意义(P<0.05)。治疗组治疗后血肌酐(Scr)、血尿素氮(BUN)、β_(2)-微球蛋白(β_(2)-MG)水平均下降,残余肾小球滤过率(rGFR)提高(P<0.05),同对照组治疗后比较,差异均有统计学意义(P<0.05)。治疗组患者治疗后腹膜功能指标均显著提升,且治疗组同对照组比较提升程度明显(P<0.05)。结论:益肾清利活络方可以改善PD患者临床症状,改善营养状态,减轻炎症状况,保护残余肾功能,改善腹膜超滤功能,提高腹透充分性,延缓腹膜纤维化进程。Objective:To observe the effect of Yishen Qingli Huoluo Prescription on patients with peritoneal dialysis(PD)and its influence on residual renal function and peritoneal function,and to explore its possible mechanism.Method:A total of 80 PD patients who visited or were hospitalized in the Nephrology Department of Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from December 2018 to August 2022 were selected and divided into treatment group and control group by random number table method,with 40 cases in each group.Both groups received conventional treatment,and the treatment group took Yishen Qingli Huoluo Prescription for 3 months on the basis of conventional treatment.The treatment results of the two groups were observed and compared.Result:The total effective rate in the treatment group was significantly higher than that in the control group(P<0.05).Compared with before treatment,the levels of prealbumin(PAB),blood albumin(ALB)and hemoglobin(Hb)in the treatment group were increased after treatment,and the levels of hypersensitive C reactive protein(hs-CRP)and interleukin-6(IL-6)were decreased(P<0.05),and compared with the control group after treatment,the differences were statistically significant(P<0.05).The levels of serum creatinine(Scr),blood urea nitrogen(BUN)andβ_(2)-microglobulin(β_(2)-MG)in the treatment group were decreased after treatment,and the residual glomerular filtration rate(rGFR)was increased(P<0.05),compared with the control group after treatment,the differences were statistically significant(P<0.05).Peritoneal function indexes of the treatment group were significantly improved after treatment,and the improvement degree of the treatment group were significantly higher than those of the control group(P<0.05).Conclusion:Yishen Qingli Huoluo Prescription can improve clinical symptoms,improve nutritional status,reduce inflammation,protect residual renal function,improve peritoneal ultrafiltration function,enhance abdominal permeability,and de

关 键 词：吴门医派络病理论 益肾清利活络方 腹膜透析 残余肾功能 腹膜功能 

分 类 号：R277.5[医药卫生—中医学]