吸入用盐酸氨溴索溶液及吸入用乙酰半胱氨酸溶液对小儿社区获得性肺炎的临床疗效对比  

Comparison of Clinical Effects of Ambroxol Hydrochloride Solution for Inhalation and Acetylcysteine Solution for Inhalation on Children with Community-acquired Pneumonia

作　　者：黄木兰 胡礼涛 陈爱英 HUANG Mulan;HU Litao;CHEN Aiying(Ganzhou Women and Children's Health Care Hospital,Jiangxi Province,Ganzhou 341000,China;不详)

机构地区：[1]江西省赣州市妇幼保健院,江西赣州341000

出　　处：《中国医学创新》2023年第22期73-76,共4页Medical Innovation of China

基　　金：赣州市指导性科技计划项目(GZ2021ZSF280)。

摘　　要：目的:比较吸入用盐酸氨溴索溶液及吸入用乙酰半胱氨酸溶液对小儿社区获得性肺炎(CAP)的临床治疗效果。方法:选取2021年11月—2023年1月赣州市妇幼保健院收治的100例CAP患儿为研究对象,用随机数字表法分为盐酸氨溴索组(n=50)与乙酰半胱氨酸组(n=50)。在常规治疗基础上,盐酸氨溴索组采用盐酸氨溴索溶液雾化吸入治疗,乙酰半胱氨酸组采用乙酰半胱氨酸溶液雾化吸入治疗,均治疗1周。比较两组临床疗效、症状体征改善时间、炎症因子水平[血清C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)]和不良反应发生情况。结果:乙酰半胱氨酸组临床总有效率为96.00%,高于盐酸氨溴索的78.00%(P<0.05)。乙酰半胱氨酸组发热、咳嗽、肺部啰音改善时间均短于盐酸氨溴索组(P<0.05)。治疗前两组CRP、SAA比较,差异均无统计学意义(P>0.05);治疗后两组CRP、SAA均降低,且乙酰半胱氨酸组均低于盐酸氨溴索组(P<0.05)。盐酸氨溴索组不良反应发生率为18.00%,乙酰半胱氨酸组不良反应发生率为10.00%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:吸入用乙酰半胱氨酸溶液较吸入用盐酸氨溴索溶液在小儿CAP中的临床疗效更显著,有助于改善患儿的症状体征,抑制炎症效应,安全性较高。Objective:To compare the clinical effects of Ambroxol Hydrochloride Solution for Inhalation and Acetylcysteine Solution for Inhalation on children with community-acquired pneumonia(CAP).Method:A total of 100 children with CAP admitted to Ganzhou Women and Children's Health Care Hospital from November 2021 to January 2023 were selected as the study objects,and were divided into Ambroxol Hydrochloride group(n=50)and Acetylcysteine group(n=50)according to random number table method.On the basis of conventional treatment,Ambroxol Hydrochloride group was treated with aerosolized inhalation of Ambroxol Hydrochloride Solution,and Acetylcysteine group was treated with aerosolized inhalation of Acetylcysteine Solution.All were treated for 1 week.The clinical effect,improvement time of symptoms and signs,levels of inflammatory factors[serum C reactive protein(CRP),serum amyloid protein A(SAA)]and occurrence of adverse reactions were compared between the two groups.Result:The total effective rate of Acetylcysteine group was 96.00%,which was higher than 78.00%of Ambroxol Hydrochloride group(P<0.05).The improvement time of fever,cough and pulmonary rale in Acetylcysteine group were shorter than those in Ambroxol Hydrochloride group(P<0.05).Before treatment,there were no significant differences in CRP and SAA between the two groups(P>0.05).After treatment,CRP and SAA were decreased in both groups,and those in Acetylcysteine group were lower than those in Ambroxol Hydrochloride group(P<0.05).The incidence of adverse reactions was 18.00%in the Ambroxol Hydrochloride group and 10.00%in the Acetylcysteine group,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with Ambroxol Hydrochloride Solution for Inhalation,Acetylcysteine Solution for Inhalation has a more significant clinical effect in children with CAP,which helps to improve the symptoms and signs of children,inhibit the inflammatory effect,and has high safety.

关 键 词：吸入用盐酸氨溴索溶液 吸入用乙酰半胱氨酸溶液 社区获得性肺炎 

分 类 号：R725.6[医药卫生—儿科]