阿奇霉素序贯疗法与持续静脉滴注治疗小儿肺炎支原体肺炎的效果比较  

Comparison of effects of Azithromycin sequential therapy and continuous intravenous infusion in treatment of mycoplasma pneumoniae pneumonia in children

作　　者：孟丽君 MENG Lijun(Department of Pediatrics of Xinyang Hospital of Traditional Chinese Medicine,Xinyang 464000 Henan,China)

机构地区：[1]信阳市中医院儿科,河南信阳464000

出　　处：《中国民康医学》2023年第13期159-162,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较阿奇霉素序贯疗法与持续静脉滴注治疗小儿肺炎支原体肺炎(MPP)的效果。方法:选取2022年12月至2023年2月该院收治的96例MPP患儿进行前瞻性研究,依据随机数字表法将其分为观察组和对照组各48例。对照组采用阿奇霉素持续静脉滴注治疗,观察组采用阿奇霉素序贯疗法(静脉滴注3 d,停药4 d,再口服给药3 d)治疗。比较两组临床疗效,咳嗽、肺部啰音消失时间及退热时间,治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)]水平及不良反应发生率。结果:观察组治疗总有效率为95.83%(46/48),对照组治疗总有效率为91.67%(44/48),组间比较差异无统计学意义(P>0.05);两组咳嗽消失时间、肺部啰音消失时间、退热时间及治疗后血清TNF-α、IL-6、hs-CRP水平比较,差异均无统计学意义(P>0.05);观察组不良反应发生率为4.17%(2/48),低于对照组的16.67%(8/48),差异有统计学意义(P<0.05)。结论:阿奇霉素序贯疗法与持续静脉滴注治疗小儿MPP的效果相当,均能改善患儿临床症状,降低TNF-α、IL-6、hs-CRP水平,但序贯疗法不良反应少,安全性高。Objective:To compare effects of Azithromycin sequential therapy and continuous intravenous infusion in treatment of mycoplasma pneumoniae pneumonia(MPP)in children.Methods:A prospective study was conducted on 96 children with MPP admitted to this hospital from December 2022 to February 2023.These children were divided into observation group and control group according to the random number table method,48 cases in each group.The control group was treated with continuous intravenous infusion of Azithromycin,while the observation group was treated with Azithromycin sequential therapy(intravenous infusion for 3 days,withdrawal for 4 days,and oral administration for 3 days).The clinical efficacy,the cough and pulmonary rales disappearance time,the antipyretic time,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)]before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.83%(46/48),that of the control group was 91.67%(44/48),and there was no significant difference between the two groups(P>0.05).There were no significant differences in the cough and pulmonary rales disappearance time,the antipyretic time and the serum levels of TNF-α,IL-6 and hs-CRP after the treatment between the two groups(P>0.05).The incidence of adverse reactions in the observation group was 4.17%(2/48),which was lower than 16.67%(8/48)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Azithromycin sequential therapy and continuous intravenous infusion have the equivalent effects on MPP in the children.They can improve the clinical symptoms and reduce the levels of TNF-α,IL-6 and hs-CRP.However,the sequential therapy has fewer adverse reactions and higher safety.

关 键 词：小儿 肺炎支原体肺炎 阿奇霉素 序贯疗法 静脉滴注 炎性因子 不良反应 

分 类 号：R725.6[医药卫生—儿科]