棕榈酸诱导胰岛β细胞功能障碍的分子机制研究进展  

Research progress of molecular mechanism of palmitic acid-induced pancreatic β-cell dysfunction

作　　者：张茜 王瑞 于智超 张硕 黄延芹[2] Zhang Xi;Wang Rui;Yu Zhichao;Zhang Shuo;Huang Yanqin(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine;Endocrinology Department,Affiliated Hospital of Shandong University of Traditional Chinese Medicine)

机构地区：[1]山东中医药大学中医学院,济南250014 [2]山东中医药大学附属医院内分泌科,济南250014

出　　处：《重庆医科大学学报》2023年第7期831-839,共9页Journal of Chongqing Medical University

基　　金：国家自然科学基金面上资助项目(编号:81974562和81603613);泰山学者工程专项资助项目(编号:tsqn202211354);钱秋海全国名老中医药专家传承工作室资助项目(编号:国中医药人教函[2022]75号);济南市科技创新发展计划资助项目(编号:202019029)。

摘　　要：2型糖尿病(type 2 diabetes mellitus,T2DM)在临床上是以存在绝对或相对的胰岛素缺乏为特点的一种常见的代谢性疾病。胰岛β细胞是胰岛素分泌和血糖控制的核心。近年来研究发现,棕榈酸可直接或间接诱导胰岛β细胞功能障碍,这与T2DM的发生发展关系密切。但具体机制复杂,仍未充分阐明。因此,探究棕榈酸诱导胰岛β细胞功能障碍的分子机制一直是临床的迫切需要。本文综述了棕榈酸与胰岛β细胞内氧化应激、内质网应激、炎症反应、自噬、增殖、去分化和线粒体相关内质网膜相关分子机制的研究进展,并讨论临床改善胰岛β细胞功能的新靶点和新思路,以期为进一步有关T2DM的机制研究和临床治疗提供参考。Type 2 diabetes mellitus(T2DM)is a common metabolic disease characterized by absolute or relative insulin deficiency clinically.Pancreaticβ-cells are the core of insulin secretion and blood glucose control.In recent years,researches have found that palmitic acid can directly or indirectly induce pancreaticβ-cell dysfunction,which is closely related to the occurrence and development of T2DM.However,the specific mechanisms are complex and have not been fully elucidated.Therefore,exploring the molecular mechanism of pancreaticβ-cell dysfunction induced by palmitic acid has always been an urgent need in clinical research.This article reviews the research progress of the relationship between palmitic acid and pancreaticβ-cells on molecular mechanisms related to oxidative stress,endoplasmic reticulum stress,inflammatory response,autophagy,proliferation,dedifferentiation,and mitochondriaassociated endoplasmic reticulum membranes,and discusses new targets and ideas for improving pancreaticβ-cell function clinically,in order to provide references for further researches on the mechanism and clinical treatment of T2DM.

关 键 词：胰岛Β细胞 2型糖尿病 棕榈酸 炎症反应 氧化应激 内质网应激 增殖 

分 类 号：R587.1[医药卫生—内分泌]