基于细胞亲和的抗瘢痕纳米经皮给药制剂研究进展  

Research progress on anti-scar nano-transdermal drug delivery based on cell affinity

作　　者：庄泽槟 刘冬榕 姚碧金 覃楚悦 时军 ZHUANG Ze-bin;LIU Dong-rong;YAO Bi-jin;QIN Chu-yue;SHI Jun(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangdong Engineering&Technology Research Center of Precise Drug Delivery System,Guangzhou 510006,China)

机构地区：[1]广东药科大学中药学院,广东广州510006 [2]广东省局部精准递药制剂工程技术研究中心,广东广州510006

出　　处：《中草药》2023年第13期4359-4366,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82173982);广东省自然科学基金资助项目(2022A1515011382)。

摘　　要：瘢痕是各种创伤所引起的正常皮肤组织外观形态和组织病理变化的总称,严重影响患者的容貌,且易引起肢体功能障碍和不适等。细胞亲和性是药物制剂能否在疾病部位稳定释放并充分发挥疗效的主要影响因素。伤口愈合过程的复杂性导致瘢痕的形成受到多种因素的影响,基于细胞亲和性能设计瘢痕治疗的纳米靶向经皮给药制剂,可有效提高治愈率。通过对细胞亲和性设计的防治瘢痕纳米靶向经皮制剂进行综述,为更多瘢痕防治策略的开发与临床应用提供参考。Scar is a general term for the appearance,morphology,and histopathological changes of normal skin tissue caused by various types of trauma,which seriously affects the appearance of patients and can easily cause limb dysfunction and discomfort.Cell affinity is the main influencing factor for the stable release and full efficacy of drug formulations at disease sites.The complexity of wound healing process leads to the formation of scars being influenced by various factors.The design of nano targeted percutaneous drug delivery formulations for scar treatment based on cell affinity performance can effectively improve the healing rate.This review provides a reference for the development and clinical application of scar prevention and treatment strategies through the review of cell affinity designed nano-transdermal formulations for scar prevention and treatment.

关 键 词：纳米靶向制剂 细胞亲和 经皮给药 瘢痕 脂质体 纳米粒 微乳 外泌体 

分 类 号：R283[医药卫生—中药学]