洋紫荆的化学成分研究  

Chemical constituents from Bauhinia variegate

作　　者：梁蒙 王亚凤[1] 李小梅 何瑞杰[1] 谢桃结 阳丙媛 朱鸿杰 黄永林[1] LIANG Meng;WANG Ya-feng;LI Xiao-mei;HE Rui-jie;XIE Tao-jie;YANG Bing-yuan;ZHU Hong-jie;HUANG Yong-lin(Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization,Guangxi Institute of Botany,Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences,Guilin 541006,China;Guilin Medical University,School of Pharmacy,Guilin 541004,China;Liuzhou Institute of Gardening,Liuzhou 545005,China)

机构地区：[1]广西壮族自治区中国科学院广西植物研究所,广西植物功能物质与资源持续利用重点实验室,广西桂林541006 [2]桂林医学院药学院,广西桂林541004 [3]柳州市园林科学研究所,广西柳州545005

出　　处：《中草药》2023年第14期4427-4432,共6页Chinese Traditional and Herbal Drugs

基　　金：柳州市科技攻关项目(2019B0801b006);国家自然科学基金项目(82060764);广西科学院基本科研业务费项目(CQZ-C-1901);桂林市创新平台与人才计划项目(20210102-3)。

摘　　要：目的 对洋紫荆Bauhinia variegate的化学成分进行研究。方法 综合利用Sephadex LH-20、Chromatorex C_(18)、Diaion HP20SS等柱色谱分离技术进行分离纯化,并综合应用HR-ESI-MS、NMR、ECD等多种波谱方法鉴定化合物结构。结果 从洋紫荆花的甲醇提取物中分离得到8个化合物,分别鉴定为4,6-二羟基亚环己基乙腈-8-β-D-葡萄糖苷(1)、L-色氨酸(2)、咖啡酸甲酯(3)、对羟基苯甲酸β-D-吡喃葡萄糖酯苷(4)、山柰酚-3-O-α-L-鼠李糖苷(5)、山柰酚-3-O-β-芸香苷(6)、山柰酚-5-O-[α-L-鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷](7)、kaempferol3-O-β-glucopyranosyl(1→2)[α-rhamnopyranosyl(1→6)]-β-glucopyranoside(8)。结论 化合物1为新化合物,命名为蝙蝠葛氰苷G,化合物2~6、8为首次从洋紫荆中分离得到。Objective To investigate the chemical constituents of Bauhinia variegate.Methods The methanol extract of flowers of B.variegate was isolated and purified by column chromatographies with Sephadex LH-20,Chromatorex C_(18),Diaion HP20SS.And their structures were identified by various spectroscopic methods,such as HR-ESI-MS,NMR,ECD,et al.Results A total of eight compounds were isolated from the extract of flowers of B.variegate.Their structures were identified as 4,6-dihydroxycyclohexylideneacetonitrile-8-β-D-glucoside(1),L-tryptophan(2),methyl caffeate(3),p-hydroxybenzoyl-β-Dglucopyranoside(4),kaempferol-3-O-α-L-rhamnoside(5),kaempferol-3-O-β-rutidine(6),kaempferol-5-O-[α-L-rhamnol-(1→6)-β-D-glucuronoside](7),kaempferol 3-O-β-glucopyranosyl(1→2)[α-rhamnopyranosyl(1→6)]-β-glucopyranoside(8).Conclusion Compound 1 is a new compound named menisdaurin G.Compounds 2—6 and 8 were obtained from the plant for the first time.

关 键 词：洋紫荆 生物碱 蝙蝠葛氰苷G 咖啡酸甲酯 山柰酚-3-O-α-L-鼠李糖苷 山柰酚-3-O-β-芸香苷 

分 类 号：R284.1[医药卫生—中药学]