乌头属二萜生物碱的抗肿瘤活性研究进展  

Progress in antitumor activity of diterpenoid alkaloids in plants of Aconitum

作　　者：陈晓峥 程菊 石小艺 杨立苑 谢小冬 CHEN Xiao-zheng;CHENG Ju;SHI Xiao-yi;YANG Li-yuan;XIE Xiao-dong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Institute of Genetics,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]兰州大学,基础医学院遗传学研究所,甘肃兰州730000

出　　处：《中国中药杂志》2023年第14期3765-3773,共9页China Journal of Chinese Materia Medica

基　　金：甘肃省自然科学基金项目(20JR10RA600);兰州市科技局新冠肺炎防控技术研究项目(2020-XG-37);2022年甘肃省科技重大专项项目(22ZD1FA001)。

摘　　要：小分子化合物由于来源丰富,结构与活性多样,在新药研发中具有独特的优势和潜力,其中传统中药材中的诸多活性成分更是为新型抗肿瘤药物的发现提供了新思路。乌头属植物是传统药用植物,多具有祛风除湿、温经止痛之功效,临床上具有抗炎镇痛、抗风湿、强心扩血管、抗肿瘤的作用。二萜生物碱作为乌头属植物的主要有效成分,可分为C20-二萜生物碱、C19-二萜生物碱、C18-二萜生物碱以及双二萜生物碱。多项研究证实二萜生物碱能有效治疗肺癌、肝癌、乳腺癌以及结肠癌等多种癌症,被认为是目前最具有抗癌前景的天然化合物。该文综述了近年来从乌头属植物中提取的C20-二萜生物碱、C19-二萜生物碱、C18-二萜生物碱和双二萜生物碱的化学结构及其抗肿瘤活性的研究进展,阐述了相关构效关系,为进一步开发乌头属二萜生物碱作为抗肿瘤药物提供参考。Small-molecule compounds with rich sources have diverse structures and activities.The active ingredients in traditional Chinese medicine(TCM)provide new sources for the discovery of new antitumor drugs.Aconitum plants as Chinese medicinal plants have the effects of dispelling wind,removing dampness,warming meridian,and relieving pain.They are mainly used to treat inflammation,pain,rheumatism,and tumors,improve heart function,and dilate blood vessels in clinical practice.Diterpenoid alkaloids are the main active components of Aconitum plants,including C20-,C19-,C18-diterpenoid alkaloids and bis-diterpenoid alkaloids.Stu-dies have demonstrated that diterpenoid alkaloids can effectively treat lung cancer,liver cancer,breast cancer,colon cancer and other cancers.Diterpenoid alkaloids are considered as the most promising natural compounds against cancers.In this review,we summarized the chemical structures and antitumor activities of C20-,C19-,C18-diterpenoid alkaloids and bis-diterpenoid alkaloids extracted from plants of Aconitum,aiming to provide reference for further development of diterpenoid alkaloids from Aconitum as antitumor drugs.

关 键 词：乌头属 二萜生物碱 抗肿瘤 

分 类 号：R285[医药卫生—中药学]