基于AHP-CRITIC复合加权法优选厚朴姜炙工艺及姜炙前后化学成分变化研究  

Processing Magnoliae Officinalis Cortex with ginger juice:process optimization based on AHP-CRITIC weighting method and composition changes after processing

作　　者：祁玉芳 范星晨 汪思晨 苏雨桉 张科卫[1] 毛春芹[1] 陆兔林[1] QI Yu-fang;FAN Xing-chen;WANG Si-chen;SU Yu-an;ZHANG Ke-wei;MAO Chun-qin;LU Tu-lin(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023

出　　处：《中国中药杂志》2023年第14期3806-3814,共9页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2018YFC1707000)。

摘　　要：以外观性状、标准汤剂出膏率及厚朴酚与和厚朴酚总含量为考察指标,通过比较层次分析法(analytic hierarchy process,AHP)、基于指标相关性的权重确定方法(criteria importance though intercrieria correlation,CRITIC)、AHP-CRITIC复合加权法确定各指标的权重系数并计算多指标综合评分,结合Box-Behnken响应面法考察姜汁用量、闷润时间、炒制温度、炒制时间对姜厚朴质量的影响,在此基础上得到厚朴姜炙的最佳工艺参数,再以水代替姜汁,比较分析厚朴、姜厚朴、水厚朴三者差异,初步探讨厚朴姜炙的炮制机制。结果显示采用AHP-CRITIC复合加权法确定外观性状、标准汤剂出膏率及厚朴酚与和厚朴酚总含量的权重系数分别为0.134、0.287、0.579。厚朴姜炙的最佳工艺为姜汁用量8%、闷润时间120 min、炒制温度100℃、炒制时间7 min。厚朴经姜炙后紫丁香酚苷和木兰花碱含量均降低,厚朴、姜厚朴及水厚朴中厚朴酚与和厚朴酚含量由高到低依次为姜厚朴>厚朴>水厚朴,推测厚朴姜炙后临床疗效发生变化与内在成分变化相关。优化所得的厚朴姜炙工艺稳定、可行,可以为其现代化生产加工过程提供参考。The weight coefficients of appearance traits,extract yield of standard decoction,and total content of honokiol and magnolol were determined by analytic hierarchy process(AHP),criteria importance though intercrieria correlation(CRITIC),and AHPCRITIC weighting method,and the comprehensive scores were calculated.The effects of ginger juice dosage,moistening time,processing temperature,and processing time on the quality of Magnoliae Officinalis Cortex(MOC)were investigated,and Box-Behnken design was employed to optimize the process parameters.To reveal the processing mechanism,MOC,ginger juice-processed Magnoliae Officinalis Cortex(GMOC),and water-processed Magnoliae Officinalis Cortex(WMOC)were compared.The results showed that the weight coefficients of the appearance traits,extract yield of standard decoction,and total content of honokiol and magnolol determined by AHP-CRITIC weighting method were 0.134,0.287,and 0.579,respectively.The optimal processing parameters of GMOC were ginger juice dosage of 8%,moistening time of 120 min,and processing at 100℃for 7 min.The content of syringoside and magnolflorine in MOC decreased after processing,and the content of honokiol and magnolol followed the trend of GMOC>MOC>WMOC,which suggested that the change in clinical efficacy of MOC after processing was associated with the changes of chemical composition.The optimized processing technology is stable and feasible and provides references for the modern production and processing of MOC.

关 键 词：厚朴 姜炙 工艺优化 AHP-CRITIC复合加权法 Box-Behnken响应面法 含量测定 成分变化 

分 类 号：R283.1[医药卫生—中药学]