苯环喹溴铵治疗以流涕为主的季节性变应性鼻炎多中心疗效观察  

A multi-center observation of the therapeutic efficacy of Bencycloquidium bromide in the treatment of seasonal allergic rhinitis with predominant symptoms of rhinorrhea

作　　者：胡伟倪 张天虹[2] 张迎宏[1] 孟超[1] 谢立锋[1] 宋昱[1] 杜晨[1] 徐驰宇[1] 杜雅丽[1] 左强[1] 安凤杨 王玉辉 孟粹达[3] 张蕾[2] 朱冬冬[3] 朱丽[1] HU Weini;ZHANG Tianhong;ZHANG Yinghong;MENG Chao;XIE Lifeng;SONG Yu;DU Chen;XU Chiyu;DU Yali;ZUO Qiang;AN Fengyang;WANG Yuhui;MENG Cuida;ZHANG Lei;ZHU Dongdong;ZHU Li(Department of Otolaryngology Head and Neck Surgery,Peking University Third Hospital,Beijing,100191,China;Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Harbin Medical University;Department of Otolaryngology Head and Neck Surgery, China-Japanese Friendship Hospital, Jilin University)

机构地区：[1]北京大学第三医院耳鼻咽喉头颈外科,北京100191 [2]哈尔滨医科大学附属第一医院耳鼻咽喉头颈外科 [3]吉林大学中日联谊医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2023年第7期550-555,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：人工智能赋能健康中国社会实验研究(No:2020AAA0105404);“北京大学-青岛”计算社会科学研究基金(No:20220005)。

摘　　要：目的:多中心观察M受体拮抗剂苯环喹溴铵鼻喷雾剂治疗以流涕为主要症状的季节性变应性鼻炎(SAR)患者的疗效及安全性。方法:纳入2021年8月-2021年9月北京大学第三医院、吉林中日联谊医院、哈尔滨医科大学附属第一医院耳鼻喉科门诊以流涕为主的SAR患者134例,其中男71例,女63例,中位年龄38岁。用苯环喹溴铵鼻喷雾剂治疗,4次/d,每次2喷90μg,用药14 d后,观察疗效及安全性。结果:受试者鼻部症状TNSS评分由第0天的(8.89±3.31)分下降至(3.71±2.51)分(P<0.001),鼻部总症状VAS评分由第0天的(24.86±7.40)分下降至用药第14天的(6.84±5.94)分(P<0.001),流涕症状VAS评分由第0天的(6.88±2.06)分下降至用药第14天的(1.91±1.81)分(P<0.001),鼻结膜炎生存质量调查问卷评分由第0天的(94.63±33.35)分下降至用药第14天的(44.95±32.28)分(P<0.001),整个试验过程中无严重不良事件发生。结论:M受体拮抗剂苯环喹溴铵鼻喷雾剂对季节性变应性鼻炎具有显著的疗效和良好的安全性。Objective:To observe the efficacy and safety of the M receptor antagonist Bencycloquidium bromide nasal spray in treatment of seasonal allergic rhinitis with runny nose as the main symptom.Methods:From August 2021 to September 2021,134 patients with seasonal allergic rhinitis were enrolled in the otolaryngology Outpatient Department of Peking University Third Hospital,First Affiliated Hospital of Harbin Medical University and China-Japanese Friendship Hospital of Jilin University,including 71 males and 63 females,with a median age of 38 years.TNSS score and visual analogue scale(VAS) of total nasal symptoms were observed during 2 weeks of treatment with Bencycloquidium bromide nasal spray.Results:TNSS score decreased from(8.89±3.31) on day 0 to(3.71±2.51) on day 14(P0.001),VAS score of nasal symptoms decreased from(24.86±7.40) on day 0 to(6.84±5.94) on day 14(P0.001),VAS score of rhinorrhoea decreased from(6.88±2.06) on day 0 to(1.91±1.81) on day 14(P0.001).Rhinoconjunctivitis quality of life questionnaire(RQLQ) score decreased from(94.63±33.35) on day 0 to(44.95±32.28) on day 14(P0.001).The incidence of adverse reaction was low and no serious adverse events occurred during the whole experiment.Conclusion:Bencycloquidium bromide nasal spray has significant efficacy and good safety in the treatment of seasonal allergic rhinitis.

关 键 词：变应性鼻炎 胆碱能受体拮抗剂 鼻喷剂 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]