Murray定律在评价颈动脉粥样硬化风险中的临床应用研究  

Clinical application of Murray's Law in assessing the risk of carotid atherosclerosis

作　　者：李新秀 夏莹莹 张贺 李若涵 韩翠平 庄银苹 LI Xinxiu;XIA Yingying;ZHANG He;LI Ruohan;HAN Cuiping;ZHUANG Yinping(School of Medical Imaging,Xuzhou Medical University,Xuzhou,Jiangsu Province 221004,China;Department of Imaging,the Afiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu Province 221000,China)

机构地区：[1]徐州医科大学医学影像学院,江苏徐州221004 [2]徐州医科大学附属医院影像科,江苏徐州221000

出　　处：《实用放射学杂志》2023年第7期1071-1074,1084,共5页Journal of Practical Radiology

基　　金：徐州市科技计划项目(KC21164)。

摘　　要：目的探讨Murray定律评估正常和颈动脉粥样硬化(CAS)患者的颈动脉分叉结构差异及其在CAS风险评估中的临床应用价值。方法回顾性分析90例CAS患者的CT血管成像(CTA)图像,根据血管狭窄程度分为轻、中、重度CAS亚组并与30例健康志愿者的CTA图像(对照组)相比较。测量原始形态参数颈总动脉分叉角(α)及直径(Dm),颈内动脉直径(Di),颈外动脉直径(De)和颈动脉窦直径(D0)。进一步分析形态学参数颈总动脉截面积扩张率(AER)、颈内动脉窦截面积扩张率(AER0)、分叉角度偏离量(α’)、分叉直径指数(n)和分叉指数偏离量(n’),比较CAS亚组与对照组颈动脉分叉结构差异。结果中、重度CAS组Dm和Di均高于对照组,差异有统计学意义(P<0.05)。轻度CAS组与对照组相比,AER0增大,差异有统计学意义(P<0.05)。CAS亚组α’高于对照组,差异有统计学意义(P<0.05),其他指标无统计学差异。结论CAS患者较正常颈动脉分叉结构存在差异且显著偏离Murray定律,对CAS的风险评估具有重要意义。Objective To investigate Murray's Law in assessing the bifurcation structure of carotid artery between normal and carotid atherosclerosis(CAS)patients and its clinical application value in CAS risk assessment.Methods The computed tomography angiography(CTA)images of 90 CAS patients were analyzed retrospectively,and they were divided into mild,moderate and severe CAS subgroup according to the degree of vascular stenosis,and 30 CTA images of healthy volunteers were selected as the control group.The primary morphologic parameters were measured:theαand Dm,Di,Deand D0.Morphological parameters were further analyzed,including common carotid artery cross-sectional area expansion rate(AER),AERo,α',n and n',and carotid artery bifurcation structure difference between CAS subgroup and control group was compared.Results Dm and Di in moderate and severe CAS groups were higher than those in control group,and the difference was statistically significant(P<o.05).Mild CAS group compared with control group,AER0 increased,the difference was statistically significant(P<0.05).The α' in CAS subgroup was higher than that of control group,the difference was statistically significant(P<0.05),there was no statistical difference in other indexes in group study.Conclusion The bifurcation structure of carotid artery in CAS patients is different from that of normal carotid artery and deviated significantly from Murray's Law,which is of great significance for the risk assessment of CAS.

关 键 词：Murray定律 颈动脉粥样硬化 颈动脉分叉 风险评估 计算机体层成像 血管造影术 

分 类 号：R543.4[医药卫生—心血管疾病] R814.42[医药卫生—内科学]