天然异戊烯基黄酮类化合物的化学结构和药理活性研究进展  

Research Progress on Chemical Structure and Pharmacological Activity of Natural Prenylated Flavonoids

作　　者：陈冠汝 姚媛 章睿丽 地里努尔·玉山 金阳[1] 陈立娜[1] CHEN Guanru;YAO Yuan;ZHANG Ruili;Dilnur Yushan;JIN Yang;CHEN Lina(School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;Department of Kirgiz Medicine,People's Hospital of Xinjiang Kezhou,Atushi 845350,China)

机构地区：[1]南京医科大学药学院,江苏南京211166 [2]克州人民医院柯医科,新疆阿图什845350

出　　处：《现代中药研究与实践》2023年第3期95-102,共8页Research and Practice on Chinese Medicines

基　　金：国家自然科学基金(32200316,81373895);江苏省自然科学基金资助项目(BK20191352);南京医科大学“医教西行”-科研合作西行协助共建项目。

摘　　要：异戊烯基黄酮类化合物是一类重要的天然产物,其异戊烯基侧链的存在可以显著增强黄酮类化合物的生物活性和生物利用度。通过对近5年来分离得到的新异戊烯基黄酮类化合物的结构特征及药理活性研究进展进行综述,为今后的科学研究与药物开发提供参考。Prenylated flavonoids are a class of important natural product,and the presence of prenylated side chain can significantly enhance the biological activity and bioavailability of flavonoids.The new prenylated flavonoids isolated in recent five years and their pharmacological activities have been reviewed,which may provide references for future scientific research and drug development.

关 键 词：天然产物 异戊烯基黄酮 化学结构 药理活性 

分 类 号：R285.5[医药卫生—中药学]