胆囊胆固醇结石与低血总胆固醇及低心脑血管疾病患病风险的相关性研究  

Study on the correlation between gallbladder cholesterol stones and low total cholesterol and low risk of cardiovascular and cerebrovascular diseases

作　　者：许大辉 崔乃强 牛凯军 XU Da-hui;CUI Nai-qiang;NIU Kai-jun(Department of Emergency Surgery,Tianjin Nankai Hospital,Tianjin(300100),China;不详)

机构地区：[1]天津市中西医结合医院(天津市南开医院)急诊科病房,天津300100 [2]天津市中西医结合医院(天津市南开医院)肝胆胰外科,天津300100 [3]天津医科大学公共卫生学院营养流行病学研究所,天津300070

出　　处：《中国中西医结合外科杂志》2023年第4期501-505,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探讨胆囊胆固醇结石与低血总胆固醇及心脑血管疾病患病的可能关联性。方法:选取2011—2012年天津市南开医院住院患者22150例,收集胆囊结石患者与心脑血管疾病患者的年龄、性别及高血压、糖尿病、高脂血症患病情况,观察其空腹血糖、三酰甘油、总胆固醇等指标的水平。使用多因素Logistic回归模型分析胆囊结石与心脑血管疾病患病的关联性。结果:22150例住院患者中,胆囊结石组8032例,女性占61.4%,平均年龄56.8(95%CI 56.4~57.5)岁;非胆囊结石组14118例,女性占51.0%,平均年龄57.3(95%CI 57.0~57.6)岁,两组间年龄、高血压、高脂血症患病率差异无统计学意义(P>0.05),两组性别比例、糖尿病、心脑血管疾病发生率差异有统计学意义(P<0.001)。胆囊结石患者的心脑血管疾病(包括冠心病、脑卒中)的患病率较非胆囊结石低(29.5%vs 43.2%,P<0.001)。胆囊结石患者的血总胆固醇较非胆囊结石患者低(4.31 mmol/L vs 4.34 mmol/L,P<0.001)。结论:胆囊结石与低血总胆固醇及低心脑血管疾病患病风险相关。Objective To explore the possible relationship of cholelithiasis to cardiovascular diseases(CVD).Methods The study population comprises 22150 in-patients at Tianjin NanKai hospital from January 2011 to December 2012.All participants claimed data including age,gender,hypertension,diabetes mellitus,hyperlipidemia and metabolic factors,such as fasting blood glucose,triglyceride and total serum cholesterol were searched.Multivariate Logistic regression models were used to assess the adjusted associations of Gallstone disease(GD)to CVD.Results There were 8032 GD cases with an average age of 56.8 years(95%CI 56.4-57.5)compared to an average age of 57.3 years(95%CI 57.0-57.6)in 14118 non-GD group(P>0.05).Significant differences were found in the proportion of female patients between the groups(P<0.001).The cholelithiasis group had a borderline decrease in the prevalence of hypertension and significant decrease(P<0.001)in the prevalence of diabetes compared to the non-cholelithiasis group.No significant differences were found in the prevalence of hyperlipidemia between the groups(P>0.05).Subjects with GD had a lower prevalence of CVD(29.5%)than those of the controls(43.2%,P<0.001).The difference remained when CHD and stroke constituted CVD were considered separately.Serum total cholesterol levels were lower in the cholelithiasis patients than those without disease(4.31 mmol/L vs 4.34 mmol/L,P<0.001).Conclusion Cholelithiasis is associated with decreases in both serum total cholesterol and the prevalence of CVD.

关 键 词：胆囊结石 冠心病 脑卒中 心脑血管疾病 血总胆固醇 

分 类 号：R657.4[医药卫生—外科学]