3D打印技术制备β-TCP仿生骨支架的形态结构特点及其成骨性能分析  

Prepared using 3D printing technology β- morphological and structural characteristics of TCP biomimetic bone scaffold and its osteogenic performance analysis

作　　者：牛建华 易敏 许卫星 Niu Jianhua;Yi Min;Xu Weixing(Shanghai Huangpu District Dental Disease Prevention and control Institute,Shanghai 200020)

机构地区：[1]上海市黄浦区牙病防治所,上海200020

出　　处：《口腔材料器械杂志》2023年第3期183-188,共6页Chinese Journal of Dental Materials and Devices

基　　金：上海市黄浦区科委科技项目基金(编号:HKM201727)。

摘　　要：目的 分析3D打印技术制备β-磷酸三钙(β-TCP)仿生骨支架的形态结构特点及其成骨性能。方法 随机选取24只新西兰兔,建立股骨髁部缺损模型。采用3D打印技术制备β-TCP仿生骨支架,将实验兔随机分为2组,每组12只。其中对照组未植入任何材料;实验组植入β-TCP仿生骨支架,观察4周、8周和12周后的两组骨修复结果,评价其成骨性能。结果 实验组术后第4周、8周、12周时的骨组织学评分均高于对照组,骨小梁厚度、数目、骨小梁体积/总体积均高于对照组(P<0.05)。3D打印的仿生骨支架的直径、高度、孔隙率以及抗压强度、弹性模量与天然松质骨之间的差异无统计学意义(P>0.05)。结论 3D打印技术制备的β-TCP仿生骨支架,可促进骨缺损的修复,支架形态学结构及成骨性能与松质骨相近。Objective Our study analyzed the morphostructual characteristics and osteogenic properties ofβ-Tricalcium phosphate(β-TCP)biomimetic bone scaffold frbricated by 3D printing technology.Methods Randomly select 24 experimental white rabbits and establish models of femoral condylar bone defects.Prepared using 3D printing technologyβ-TCP biomimetic bone scaffold was randomly divided into 2 groups of 12 rabbits in each group.The control group was not implanted with any materials;Experimental group was implanted withβ-TCP biomimetic bone scaffold.After 4,8 and 12 weeks of observation,the bone repair results of the two groups were compared to evaluate the osteogenic performance.Results The bone histological scores of the experimen-tal group were higher than those of the control group at weeks 4,8,and 12 after surgery.The thickness,number,and volume/total volume of bone trabeculae in the experimental group were higher than those in the control group(P<0.05).The diameter,height,porosity,compressive strength,and elastic modulus of the 3D printed bone scaf-folds had no significant differences with nature cancellous bone(P>0.05).Conclusions 3D printing technology preparationβ-TCP biomimetic bone scaffold can promote the repair of bone defects,and its morphological struc-ture and osteogenic performance are similar to those of cancellous bone.

关 键 词：Β-TCP 仿生骨支架 3D打印技术 骨修复 

分 类 号：R318.08[医药卫生—生物医学工程]