太原市乙型肝炎疫苗和乙型肝炎免疫球蛋白联合免疫阻断乙型肝炎病毒母婴传播的效果及其影响因素  

The effect of co-administration of hepatitis B vaccine and hepatitis B immunoglobulin on interrupting mother-to-child transmission of hepatitis B virus and its influencing factors in Taiyuan

作　　者：刘巧君[1] 张萍[1] 史坚 Liu Qiaojun;Zhang Ping;Shi Jian(Taiyuan Municipal Center for Disease Control and Prevention,Taiyuan 030012,Shanxi,China)

机构地区：[1]太原市疾病预防控制中心,山西太原030012

出　　处：《中国疫苗和免疫》2023年第3期332-335,共4页Chinese Journal of Vaccines and Immunization

基　　金：中国肝炎防治基金会-中国乙肝防控科研基金资助课题(YGFK20190092)。

摘　　要：目的 评价乙型肝炎(乙肝)疫苗(Hepatitis B vaccine, HepB)和乙肝免疫球蛋白(Hepatitis B immunoglobulin, HBIG)联合免疫阻断乙肝病毒(Hepatitis B virus, HBV)母婴传播的效果和影响因素。方法 在太原市产科医院招募2019-2022年乙肝表面抗原(Hepatitis B surface antigen, HBsAg)阳性母亲所生新生儿,出生后联合免疫首剂次HepB和HBIG,并完成HepB全程免疫,在新生儿8-24月龄检测血清HBsAg和乙肝表面抗体(Hepatitis B surface antibody, HBsAb),分析HBV母婴传播阻断成功率和影响因素。结果 共纳入HBsAg阳性母亲所生新生儿203名,HBV母婴阻断成功率为98.03%。多因素Logistic回归分析显示乙肝e抗原(Hepatitis B e antigen, HBeAg)同时阳性母亲所生新生儿的母婴传播阻断成功率较低(OR=0.11,95%CI:0.01-0.88)。结论 HepB和HBIG联合免疫对HBsAg阳性母亲所生新生儿的HBV母婴传播阻断总体效果较好,母亲HBeAg同时阳性是影响阻断效果的独立因素。Objective To assess the effect of co-administration of hepatitis B vaccine(HepB)and hepatitis B immunoglobulin(HBIG)on interrupting mother-to-child transmission of hepatitis B virus(HBV)and its influencing factors.MethodsWe recruited infants born to hepatitis B surface antigen(HBsAg)positive mothers in obstetrics and gynecology hospitals of Taiyuan city from 2019 to 2022.Each infant received the first dose of HepB combined with HBIG and subsequent full-series HepB vaccination.We tested sera for HBsAg and hepatitis B surface antibody(HBsAb)at 8-24 months of age to determine the rate of interruption of mother-to-child transmission and risk factors of transmission.ResultsA total of 203 infants born to HBsAg-positive mothers were included;the rate of interrupting mother-to-child HBV transmission was 98.03%.Multivariate logistic regression analysis showed that the interruption rate was lowest for infants of hepatitis B e antigen(HBeAg)positive mothers before delivery(OR=0.11,95%CI:0.01-0.88).ConclusionsThe co-administration of HepB and HBIG showed significant effectiveness in interrupting mother-to-child HBV transmission among infants born to HBsAg-positive mothers.HBeAg positivity of mothers is an independent factor influencing the interruption of mother-to-child transmission.

关 键 词：乙型肝炎 乙型肝炎疫苗 乙型肝炎免疫球蛋白 联合免疫 母婴传播 阻断 效果 影响因素 

分 类 号：R512.6[医药卫生—内科学]