中国中老年男性人群患慢性疾病与可能肌少症发生风险关联的队列研究  

Association between chronic diseases and possible sarcopenia in middle-aged and older Chinese men:A prospective cohort study

作　　者：梁博 商学军 裴丽君[1] LIANG Bo;SHANG Xue-jun;PEI Li-jun(Institute of Population Research/China Center for Population Health and Development,Peking University,Beijing 100871,China;Department of Urology,Jinling Hospital,Nanjing University School of Medicine/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)

机构地区：[1]北京大学人口研究所/北京大学中国人口健康与发展研究中心,北京100871 [2]南京大学医学院附属金陵医院/东部战区总医院泌尿外科,江苏南京210002

出　　处：《中华男科学杂志》2023年第1期10-18,共9页National Journal of Andrology

基　　金：国家重点研发计划项目(2018YFC1004303);国家自然科学基金(41871360)。

摘　　要：目的:探讨我国男性中老年人患慢性疾病与可能肌少症发生风险的关联。方法:采用队列研究方法,通过测量握力和重复5次起坐时间判断可能肌少症,以中国健康与养老追踪调查2011年和2013年收集到的45岁及以上4878例未发生可能肌少症的男性作为基线人群,随访观察该队列人群至2015年。采用Cox比例风险模型探索男性患慢性病的种类和慢性病共病数与可能肌少症风险的关联。结果:患前列腺疾病、认知受损、有抑郁状况的男性发生可能肌少症的风险分别提高了16%(HR=1.16,95%CI:1.01~1.33)、23%(HR=1.23,95%CI:1.10~1.38)和12%(HR=1.12,95%CI:1.01~1.24);与不患慢性病的男性人群相比,患1种、2种和3种及以上慢性病的男性发生可能肌少症的风险分别提高了22%(HR=1.22,95%CI:1.04~1.42)、20%(HR=1.20,95%CI:1.02~1.42)和46%(HR=1.46,95%CI:1.25~1.71),可能肌少症发生风险随着患慢性病共病数的增加而升高,并且存在剂量反应关系(P<0.001)。结论:我国男性中老年人患前列腺疾病、认知受损、有抑郁状况增加其发生可能肌少症的风险,随着男性患慢性病共病数的增加,可能肌少症发生风险升高。Objective:To investigate the association between chronic diseases and the risk of possible sarcopenia among middle-aged and older Chinese males.Methods:This prospective cohort study included the data collected from the China Health and Retirement Longitudinal Study on 4878 males aged over 45 years without possible sarcopenia as the baseline population in 2011 and 2013,and all were followed up until 2015.Possible sarcopenia was determined by measuring the grip strength and the time of five successive sit-ups.The Cox proportional risk model was used to analyze the relationship of the type and number of chronic diseases with the risk of possible sarcopenia in males.Results:The risk of possible sarcopenia in the middle-aged and older men with prostatic disease,cognitive impairment or depression was increased by 16%(HR=1.16,95%CI:1.01-1.33),23%(HR=1.23,95%CI:1.10-1.38)and 12%(HR=1.12,95%CI:1.01-1.24),respectively.The risk in those with one,two or three or more chronic diseases was raised by 22%(HR=1.22,95%CI:1.04-1.42),20%(HR=1.20,95%CI:1.02-1.42)and 46%(HR=1.46,95%CI:1.25-1.71),respectively,compared with those without chronic diseases,and it was increased in a dose-dependent manner(P<0.01)Conclusion:Prostatic disease,cognitive impairment and depression increase the risk of possible sarcopenia in middle-aged and older Chinese males,and the risk rises with the increased number of chronic comorbidities.

关 键 词：可能肌少症 慢性病 中老年男性 队列研究 

分 类 号：R592[医药卫生—老年医学]