Perceiving the connection between the bone healing process and biodegradation of biodegradable metal implants through precise bioadaptability principle  

作　　者：Yufeng Zheng Xiao Liu Danni Shen Wenting Li Yan Cheng Ming Yang Yuhui Kou Baoguo Jiang 

机构地区：[1]Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China [2]School of Materials Science and Engineering,Peking University,Beijing 100871,China [3]International Research Organization for Advanced Science and Technology(IROAST),Kumamoto University,Kumamoto 860-8555,Japan [4]Department of Orthopaedics and Traumatology,Peking University People’s Hospital,Beijing 100044,China [5]Key Laboratory of Trauma and Neural Regeneration(Peking University),Ministry of Education,Beijing 100044,China [6]National Center for Trauma Medicine,Beijing 100044,China

出　　处：《Journal of Materials Science & Technology》2023年第16期132-144,共13页材料科学技术（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51931001 and U22A20121);the Fund for International Cooperation and Exchange between NSFC(China)and CNR(Italy)(NSFC–CNR No.52011530392);the Fund for International Cooperation and Exchange between NSFC(China)and RFBR(Russia)(NSFC-RFBR No.52111530042).

摘　　要：The implants made of metallic biomaterials help healing the bone fracture but also affect the bone repair process.As proposed in Matter 4(2021)2548–2650 by Wang et al.,a precisely adaptable biomaterial ought to recapitulate the targeted tissue with spatiotemporal precision and hierarchical accuracy,ranging from atoms and molecules(genes,proteins,etc.)to cells(including organelles)and to tissues and organs.In comparison to traditional bio-inert metallic bone implants such as Co-based alloys and Ti alloys,biodegradable metal(Mg and Zn alloys)bone implants had been developed and might arise many unexpected variables in the bone repair,due to their bioactive nature.In this paper,the bone repair without and with the presence of metallic implants is compared.Thereafter,the perspectives concerning the interactions between the bone tissues and biodegradable metal implants are put forward,and how to better mimic in vivo biodegradation by in vitro experiments is proposed for further research and development of biodegradable metals.

关 键 词：Biodegradable metals MAGNESIUM ZINC Bone healing Precise bioadaptability 

分 类 号：TG139.8[一般工业技术—材料科学与工程] R318.08[金属学及工艺—合金]