血清PGRN、SFRP1、CCL26与支气管哮喘急性发作期患者肺功能和气道炎症的相关性研究  

Correlation Study of Serum PGRN,SFRP1 and CCL26 and Lung Function and Airway Inflammation in Patients with Acute Attack Stage of Bronchial Asthma

作　　者：申燕华 杭宇[1] 危蕾 王众福 李莉[1] SHEN Yan-hua;HANG Yu;WEI Lei;WANG Zhong-fu;LI Li(Department of Respiratory Medicine,Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201999,China)

机构地区：[1]上海中医药大学附属曙光医院宝山分院呼吸内科,上海201999

出　　处：《现代生物医学进展》2023年第15期2873-2877,共5页Progress in Modern Biomedicine

基　　金：上海市卫生健康委员会科研项目(2018LQ001)。

摘　　要：目的:探讨支气管哮喘(BA)急性发作期患者血清颗粒蛋白前体(PGRN)、分泌型卷曲相关蛋白1(SFRP1)、C-C基序趋化因子配体26(CCL26)与肺功能和气道炎症的相关性。方法:选取2021年1月~2022年6月我院收治的118例BA急性发作期患者作为急性发作期组,根据病情分级将BA急性发作期患者分为轻度亚组55例、中度亚组43例、重度亚组20例,另选取同期77例BA临床控制期患者(临床控制期组)和60例体检健康志愿者(对照组)分别作为对照。采用Pearson相关性分析BA急性发作期患者血清PGRN、SFRP1、CCL26水平与肺功能和气道炎症指标的相关性。结果:对照组、临床控制期组、急性发作期组血清PGRN水平和第1秒用力呼气容积占预计值百分比(FEV_(1)%pred)、峰值呼气流速(PEF)依次降低,SFRP1、CCL26水平和呼出气一氧化氮(FeNO)、外周血嗜酸性粒细胞(EOS)计数依次升高(P<0.05)。轻度亚组、中度亚组、重度亚组血清PGRN水平和FEV_(1)%pred、PEF依次降低,SFRP1、CCL26水平和FeNO、外周血EOS计数依次升高(P<0.05)。Pearson相关性分析显示,BA急性发作期患者血清PGRN水平与FEV_(1)%pred、PEF呈正相关,与FeNO、外周血EOS计数呈负相关(P<0.05),SFRP1、CCL26与FEV_(1)%pred、PEF呈负相关,与FeNO、外周血EOS计数呈正相关(P<0.05)。结论:BA急性发作期患者血清PGRN水平降低,SFRP1、CCL26水平升高,与病情严重程度、肺功能和气道炎症有关,可能成为BA急性发作期患者新的治疗靶点。Objective:To investigate the correlation between serum progranulin(PGRN),secreted frizzled related protein 1(SFRP1)and C-C motif chemokine ligand 26(CCL26)and lung function and airway inflammation in patients with acute attack stage of bronchial asthma(BA).Methods:118 patients with acute attack stage of BA who were admitted to our hospital from January 2021 to June 2022 were selected as the acute attack stage group.According to the disease grade,the patients with acute attack stage of BA were divided into mild subgroup with 55 cases,moderate subgroup with 43 cases and severe subgroup with 20 cases.Another 77 patients with clinical control period of BA(clinical control period group)and 60 healthy volunteers in physical examination(control group)were selected as controls respectively in the same period.Pearson correlation was used to analyze the correlation between serum PGRN,SFRP1,CCL26 levels and lung function and airway inflammation indicators in patients with acute attack stage of BA.Results:The serum PGRN level,the forced expiratory volume in one second%(FEV_(1)%pred)and the peak expiratory flow(PEF)in the control group,the clinical control period group and the acute attack stage group were decreased successively,the SFRP1 and CCL26 levels,fractional exhaled nitric oxide(FeNO)and peripheral blood eosinophil(EOS)count were increased successively(P<0.05).Serum PGRN level,FEV,%pred and PEF in the mild subgroup,moderate subgroup and severe subgroup were decreased successively,while SFRP1,CCL26 levels,FeNO and peripheral blood EOS count were increased successively(P<0.05).Pearson correlation analysis showed that serum PGRN level was positively correlated with FEV_(1)%pred and PEF,and negatively correlated with FeNO and peripheral blood EOS count(P<0.05),SFRPI and CCL26 were negatively correlated with FEV_(1)%pred and PEF,they were positively correlated with FeNO and peripheral blood EOS count(P<0.05).Conclusion:Patients with acute attack stage of BA have reduced serum PGRN level and increased SFRP1 and CCL26 levels

关 键 词：支气管哮喘 急性发作期 PGRN SFRP1 CCL26 肺功能 气道炎症 相关性 

分 类 号：R562.25[医药卫生—呼吸系统]