血清降钙素原、可溶性血管内皮生长因子受体1及sofa评分与重症感染的相关性及预后预测价值  

Correlation of Serum Procalcitonin,Soluble Vascular Endothelial Growth Factor Receptor 1 and Sofa Score with Severe Infection and Prognostic Value

作　　者：龙训辉[1] 陈健[1] 王齐国[1] 生娣 许玲[1] LONG Xun-hui;CHEN Jian;WANGQi-guo;SHENG Di;XU Ling(Department ofIntensive Care Medicine,The Fourth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,830011,China)

机构地区：[1]新疆医科大学第四附属医院重症医学科,新疆乌鲁木齐830011

出　　处：《现代生物医学进展》2023年第15期2878-2882,共5页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2022D01C808)。

摘　　要：目的:探讨血清降钙素原(PCT)、可溶性血管内皮生长因子受体1(sFIt-1)及序贯器官衰竭(sofa)评分与重症感染的相关性及预后预测价值。方法:选取我院2020年1月到2022年12月收治的60例重症感染患者作为研究对象,依照感染严重程度分为脓毒症组(n=25),重度脓毒症组(n=20)与脓毒症休克组(n=15),另选取同期来我院体检的30名健康者作为对照组。对比四组受检者PCT、sFIt-1、sofa评分水平,分析PCT、sFIt-1、sofa与重症感染的相关性。通过对60例重症感染患者的治疗结果情况分为存活组(n=36)和死亡组(n=24),对比两组患者临床一般情况和PCT、sFIt-1、sofa评分水平,并应用;logistic回归分析分析三者对重症感染的预后预测价值。结果:四组受检者PCT、sFIt-1、sofa评分水平对比差异显著,脓毒症休克组高于重度脓毒症组、脓毒症组和对照组(P<0.05);Spearman相关分析结果显示:PCT、sFIt-1、sofa评分与重症感染呈正相关(P<0.05);存活组与死亡组患者性别、年龄、感染部位、合并冠心病、糖尿病、高血压基础疾病、病原学、重症监护室(Intensive Care Unit,ICU)住院时间对比无差异(P>0.05),存活组与死亡组患者合并心功能不全、急性生理与慢性健康评分(APACHEⅡ)评分、PCT、sFIt-1、sofa评分对比差异显著(P<0.05);logistic回归分析结果表明:PCT、sFIt-1、sofa评分为重度感染预后的独立预测指标(P<0.05)。结论:PCT、sFIt-1、sofa与重症感染呈正相关,且三者水平越高患者死亡率可能越高,因此需针对PCT、sFIt-1、sofa升高的感染患者改良治疗措施,预防预后不良情况。Objective:To explore the correlation between serum procalcitonin(PCT),soluble vascular endothelial growth factor receptor 1(sFIt-1)and sequential organ failure(sofa)scores and severe infection and the prognostic value.Methods:60 patients with severe infection admitted to our hospital from January 2020 to December 2022 were selected as the study subjects.According to the severity of infection,they were divided into sepsis group(n=25),severe sepsis group(n=20)and septic shock group(n=15).In addition,30 healthy people who came to our hospital for physical examination at the same time were selected as the control group.The scores of PCT,sFIT-1 and sofa were compared among the four groups,and the correlation between PCT,sFIT-1 and sofa and severe infection was analyzed.The treatment results of 60 patients with severe infection were divided into survival group(n=36)and death group(n=24).The clinical general conditions and PCT,sFIT-1 and sofa scores of the two groups were compared and applied;Logistic regression analysis was used to analyze the prognostic value of the three factors for severe infection.Results:There were differences in PCT,sFIt-1 and sofa scores among the four groups.The level of septic shock group was significantly higher than that of severe sepsis group,sepsis group and control group(P<0.05);Spearman correlation analysis showed that PCT,sFIt-1 and sofa scores were positively correlated with severe infection(P<0.05);There was no difference between the survival group and the death group in gender,age,infection site,combined coronary heart disease,diabetes,hypertension,etiology,and length of stay in intensive care unit(ICU)(P>0.05).The survival group and the death group were combined with cardiac insufficiency,acute physiology and chronic health score(APACHE II),PCT,sFIt-1 There was significant difference in sofa score(P<0.05);The results of logistic regression analysis showed that PCT,sFIt-1 and sofa scores were independent predictors of the prognosis of severe infection(P<0.05).Conclusion:PCT,sFIt-1 an

关 键 词：PCT sFIt-1 序贯器官衰竭评分 重症感染 脓毒症 

分 类 号：R631.2[医药卫生—外科学]