尿液U-ABRBC、U-RBC及U-RBCPA联合检测在肾性血尿中诊断价值分析  

Diagnostic Value of U-ABRBC,U-RBC and U-RBCPA Combined Urine Tests in Renal Hematuria

作　　者：王喜尧[1] 黄丽娟[1] 杜桂芹[1] 徐洪伟[1] 赵博欣 WANG Xi-yao;HUANG Li-juan;DU Gui-qin;XU Hong-wei;ZHAO Bo-xin(Department of Clinical Laboratory,The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院检验科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2023年第15期2915-2919,共5页Progress in Modern Biomedicine

基　　金：黑龙江省卫生健康委项目(2019-235)。

摘　　要：目的:探讨尿液U-ABRBC、U-RBC及U-RBCPA联合检测在肾性血尿中诊断价值分析。方法:前瞻性纳入2019年1月-2022年12月在我院就诊的90例肾性血尿患者作为研究对象,并以同期体检健康者90例作为对照。采用Spearman相关性分析分析U-RBCPA、U-RBC、U-ABRBC的表达与肾性血尿的关系;采用logistics回归模型分析肾性血尿的独立危险因素;采用受试者工作曲线(ROC)分析U-RBCPA、U-RBC、U-ABRBC对肾性血尿的诊断价值。结果:研究组U-RBCPA、U-RBC显著高于对照组(P<0.05),而U-ABRBC显著低于对照组(P<0.05);U-RBCPA、U-RBC、U-ABRBC与肾性血尿密切相关(P<0.05);多因素分析结果显示,U-RBCPA、U-RBC、U-ABRBC是影响肾性血尿发生的独立危险因素(P<0.05);U-RBCPA诊断肾性血尿的敏感度75.00%,特异度76.00%和AUC值为0.721;U-RBC诊断肾性血尿的敏感度78.00%,特异度80.00%和AUC值为0.756;U-ABRBC诊断肾性血尿的敏感度73.00%,特异度72.00%和AUC值为0.722;三项指标拟合诊断诊断肾性血尿的敏感度90.00%,特异度88.00%和AUC值为0.821。结论:U-RBCPA、U-RBC、U-ABRBC的差异化表达可作为诊断评估肾性血尿的可靠实验室指标。Objective:To explore the diagnostic value of U-ABRBC,U-RBC and U-RBCPA combined urine detection in renal hematuria.Methods:90 patients with renal hematuria admited to our hospital from January 2019 to December 2022 were prospectively included as study objects,and 90 healthy patients in the same period were taken as control.Spearman correlation analysis was used to analyze the relationship between the expression of U-RBCPA,U-RBC,U-ABRBC and renal hemuria.The independent risk factors of renal hematuria were analyzed by logistics regression model.The diagnostic value of U-RBCPA,U-RBC and U-ABRBC in renal hematuria was analyzed by receiver operating curve(ROC).Results:U-RBCPA and U-RBC in the study group were significantly higher than those in the control group(P<0.05),but U-ABRBC was significantly lower than those in the control group(P<0.05).U-RBCPA,U-RBC,U-ABRBC were closely correlated with renal hemuria(P<0.05).The results of multivariate analysis showed that U-RBCPA,U-RBC and U-ABRBC were independent risk factors for renal hemuria(P<0.05).U-RBCPA had a sensitivity of 75.00%,specificity of 76.00%and AUC value of 0.721 in the diagnosis of renal hematuria.U-RBC had a sensitivity of 78.00%,specificity of 80.00%and AUC value of 0.756 in the diagnosis of renal hematuria.The sensitivity,specificity and AUC value of U-ABRBC in the diagnosis of renal hematuria were 73.00%,72.00%and 0.722.The sensitivity,specificity and AUC value were 90.00%,88.00%and 0.821 respectively.Conclusion:The differential expression of U-RBCPA,U-RBC and U-ABRBC can be used as reliable laboratory indicators for diagnosis and evaluation of renal hematuria.

关 键 词：U-ABRBC U-RBCU-RBCPA 肾性血尿 诊断价值 

分 类 号：R692.3[医药卫生—泌尿科学] R696.8[医药卫生—外科学]