视网膜Müller细胞重编程研究进展  

Research progress in the reprogramming of retinal Müller glia cells

作　　者：张小丽[1] 张书强[1] 徐绘 ZHANG Xiao-li;ZHANG Shu-qiang;XU Hui(Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education,Nantong University,Jiangsu Nantong 226001,China)

机构地区：[1]南通大学江苏省和教育部神经再生重点实验室,江苏南通226001

出　　处：《解剖学报》2023年第4期484-489,共6页Acta Anatomica Sinica

基　　金：国家自然科学基金(81970820)。

摘　　要：视网膜退行性疾病导致的失明严重影响人类健康。哺乳动物视网膜损伤后无法自我修复,而斑马鱼的视网膜具有较强的再生能力,能再生所有类型的视网膜神经元并恢复视觉。斑马鱼的视网膜再生依赖于一种神经胶质细胞——Müller细胞。斑马鱼视网膜损伤后Müller细胞重编程并增殖产生祖细胞,后者进一步分化为新生的视网膜神经元。近年来,基于Müller细胞的视网膜再生研究取得了许多重要进展。我们就斑马鱼视网膜再生的机制和哺乳动物Müller细胞重编程的研究进展做一综述。Blinding eye diseases caused by retinal degeneration have a detrimental effect on human health.Mammalian retina exhibits very limited capacity for self⁃repair after degenerative disease or injury.In contrast,zebrafish retina possesses a robust regenerative response that regenerates all types of retinal neurons and restores vision.Retina regeneration in zebrafish depends on a type of glia cells called Müller glia.Following retinal injury,zebrafish Müller glia undergo a reprogramming process and proliferate into multipotent progenitor cells that further differentiate into newborn retinal neurons.In recent years,significant progress has been made in the field of Müller glia⁃based retina regeneration.Here we summarize the mechanisms governing zebrafish retina regeneration and the recent advances in mammalian Müller glia reprogramming.

关 键 词：视网膜 再生 重编程 MÜLLER细胞 斑马鱼 

分 类 号：Q189[生物学—神经生物学]