Clavukoelloids A—M,Thirteen Rare N-Containing Nardosinane Type Sesquiterpenoids from the Soft Coral Clavularia koellikeri  

作　　者：Xiao Han Zhe Wang Anran Fu Kun Liu Zongchen Ma Xuli Tang Dahai Zhang Guoqiang Li 

机构地区：[1]Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 266003 China [2]College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, Shandong, 266100 China [3]Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, Shandong, 266235 China

出　　处：《Chinese Journal of Chemistry》2023年第12期1491-1496,共6页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.U2006204,41776136,and 2181101213)。

摘　　要：Thirteen new nitrogen-containing nardosinane-type sesquiterpenoids,clavukoelloids A-M(1-13)with unique acrylamide fragments vs.the reported general nardosinane-type sesquiterpenoids containing lactone,were isolated from the soft coral Clavularia koellikeri collected from the South China Sea.The structures and absolute configurations of new compounds were unambiguously determined by analysis of spectroscopic data,CP3,DP4+,ECD spectra,and X-ray diffraction.Compound 6 showed anti-inflammatory activities and hepatoprotective activities in transgenic fluorescent zebrafish.

关 键 词：Soft coral Clavularia koellikeri Nardosinane-type sesquiterpenoids Absolute configurations ACTIVITIES Natural products NMR spectroscopy TERPENOIDS 

分 类 号：O62[理学—有机化学]