Constructing Artificial Nucleobase Compilation to Enable Precise Molecular Medicine  

作　　者：Jingqi Chen Bo Liu Xuan Wang Xueliang Liu Dandan Yang Yu Yang 

机构地区：[1]Institute of Molecular Medicine (IMM),Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200127 China [2]Institute of Functional Nano & Soft Materials Laboratory (FUNSOM),Soochow University,Suzhou,Jiangsu,215123 China [3]Evergrande Center for Immunologic Diseases,Ann Romney Center for Neurologic Diseases,Harvard Medical School and Brigham and Women's Hospital,Boston,MA,02115 USA

出　　处：《Chinese Journal of Chemistry》2023年第11期1385-1398,共14页中国化学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.22277072 and 22107065);"Clinic Plus"Outstanding Project(Nos.2021ZYB009 and 2021ZYB003)from Shanghai Key Laboratory for Nucleic Acid Chemistry Nanomedicine;Innovative research team of high-level local universities in Shanghai.

摘　　要：Nucleic acids are the hereditary information storage medium of life. Due to its high programmability and good biocompatibility, the applications of nucleic acids are not limited to their natural function. However, the efficiency of nucleic acids is often hampered by inherent limitations in numerous practical applications, including limited access to complex functional patterns due to only four building blocks, facile degradation by nucleases, rapid renal clearance, poor pharmacokinetic properties, and so on. To end this, the researchers developed unnatural base pairs (UBPs) and numerous artificial analogues of nucleosides and oligonucleotides in recent decades. The developed UBPs and nucleoside base analogues together constitute artificial nucleobase compilation, which promotes the development of biomedical sciences. Here, we describe the development of artificial nucleobase compilation and summarized its applications in precise molecular medicine, including PCR-based diagnostics, aptamer-based diagnostics, nucleobase analogue drugs construction, ASO modification, aptamer-based therapeutics and biomaterials construction. This review provides an overview of current opportunities and challenges of artificial nucleobase-related precise molecular medicine.

关 键 词：NUCLEOBASES OLIGONUCLEOTIDES Biological activity APTAMER Drug delivery 

分 类 号：O62[理学—有机化学]