隐球菌病原学检测及脑脊液生化指标检测在艾滋病合并隐球菌感染诊断中的应用效果  

Application Effect of Cryptococcal Pathogenic Detection and Cerebrospinal Fluid Biochemical Index Detection in Diagnosis of AIDS Complicated with Cryptococcal Infection

作　　者：谢小馨 罗星星 彭银霜 宋春丽 Xie Xiaoxin;Luo Xingxing;Peng Yinshuang;Song Chunli(Infection Department,Guiyang Public Health Clinical Center,Guiyang 550001,Guizhou Province,China)

机构地区：[1]贵阳市公共卫生救治中心感染科,贵州贵阳550001

出　　处：《中国社区医师》2023年第21期93-95,共3页Chinese Community Doctors

摘　　要：目的:分析隐球菌病原学检测及脑脊液生化指标检测在艾滋病合并隐球菌感染诊断中的应用效果。方法:选取2018年2月—2021年5月贵阳市公共卫生救治中心感染科收治的艾滋病合并隐球菌感染患者40例作为研究组,选取同期未合并隐球菌感染的40例艾滋病患者作为对照组,均行脑脊液生化指标检测,研究组行隐球菌病原学检测(血清隐球菌抗原检测、脑脊液隐球菌荚膜抗原、脑脊液墨汁染色检测),比较两组脑脊液蛋白质(CSF-Pro)、脑脊液葡萄糖(CSF-Glu)和脑脊液氯化物(CSF-Cl)水平,以组织病理学检查结果为“金标准”,分析血清隐球菌抗原检测、脑脊液隐球菌荚膜抗原检测、脑脊液墨汁染色检测的诊断准确度。结果:研究组CSF-Pro水平高于对照组,CSF-Glu、CSF-Cl水平低于对照组,差异有统计学意义(P<0.001)。血隐球菌荚膜抗原检测诊断准确度为100.00%(40/40),脑脊液隐球菌荚膜抗原检测诊断准确度为95.00%(38/40),脑脊液墨汁染色检测诊断准确度为97.50%(39/40),三种检测方式的诊断准确度比较,差异无统计学意义(P>0.05)。结论:血清隐球菌抗原检测、脑脊液隐球菌荚膜抗原检测、脑脊液墨汁染色检测均能准确诊断艾滋病合并隐球菌感染,同时临床可以结合脑脊液生化指标进行辅助诊断。Objective:To analyze the application effect of cryptococcal pathogenic detection and cerebrospinal fluid biochemical index detection in the diagnosis of AIDS complicated with cryptococcal infection.Methods:A total of 40 AIDS patients with cryptococcal infection treated in the Infection Department of Guiyang Public Health Clinical Center from February 2018 to May 2021 were selected as the study group,and 40 AIDS patients without cryptococcal infection in the same period were selected as the control group.Both groups received cerebrospinal fluid biochemical index detection.The study group received cryptococcal pathogenic detection(serum cryptococcal antigen detection,cerebrospinal fluid cryptococcal capsular antigen,cerebrospinal fluid ink staining detection).The levels of cerebrospinal fluid protein(CSF-Pro),cerebrospinal fluid glucose(CSF-Glu)and cerebrospinal fluid chloride(CSF-Cl)were compared between the two groups.The histopathological examination results were used as the"gold standard"to analyze the diagnostic accuracy of serum cryptococcal antigen detection,cerebrospinal fluid cryptococcal capsular antigen detection and cerebrospinal fluid ink staining detection.Results:The levels of CSF-Pro in the study group were higher than those in the control group,and the levels of CSF-Glu and CSF-Cl in the study group were lower than those in the control group,and the difference was statistically significant(P<0.001).The diagnostic accuracy of serum cryptococcal antigen detection,cerebrospinal fluid cryptococcal capsular antigen detection,cerebrospinal fluid ink staining detection was 100.00%(40/40),95.00%(38/40),and 97.50%(39/40),and there was no statistically significant difference in the diagnostic accuracy of the three detection methods(P>0.05).Conclusion:Serum cryptococcal antigen detection,cerebrospinal fluid cryptococcal capsular antigen detection,and cerebrospinal fluid ink staining detection can accurately diagnose AIDS complicated with cryptococcal infection,and they can be combined with cerebrospinal fluid

关 键 词：艾滋病合并隐球菌感染 隐球菌病原学检测 脑脊液生化指标 

分 类 号：R519.4[医药卫生—内科学] R512.91[医药卫生—临床医学]