胺碘酮静脉滴注治疗急性心衰合并阵发性快速房颤的临床效果分析  

Clinical effect analysis of amiodarone intravenous infusion in the treatment of acute heart failure with paroxysmal atrial fibrillation

作　　者：鲁敬源 LU Jing-yuan(Chifeng Hospital,Chifeng 024000,China)

机构地区：[1]内蒙古赤峰市医院,024000

出　　处：《中国现代药物应用》2023年第14期96-99,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究胺碘酮静脉滴注治疗急性心力衰竭(心衰)合并阵发性快速心房颤动(房颤)的临床效果。方法50例急性心衰合并阵发性快速房颤患者,随机分为对照组与观察组,每组25例。对照组给予常规药物治疗,观察组在对照组基础上给予胺碘酮静脉滴注治疗。对比两组治疗效果、心功能指标[平均动脉压(MAP)、心率(HR)]、血压(收缩压、舒张压)水平及不良反应发生率。结果观察组患者治疗总有效率96.00%显著高于对照组的76.00%,差异有统计学意义(P<0.05)。治疗后,观察组患者MAP(106.43±6.51)mm Hg(1 mm Hg=0.133 kPa)与HR(80.04±4.23)次/min显著低于对照组的(121.86±10.24)mm Hg、(103.82±9.67)次/min,差异有统计学意义(P<0.05)。治疗后,观察组患者舒张压(78.57±8.63)mm Hg与收缩压(112.00±9.13)mm Hg显著低于对照组的(89.06±7.04)、(125.86±12.74)mm Hg,差异有统计学意义(P<0.05)。观察组不良反应发生率为8.00%,显著低于对照组的32.00%,差异有统计学意义(P<0.05)。结论在急性心衰合并阵发性快速房颤中给予胺碘酮静脉滴注治疗,能够有效改善患者的心功能及血压水平,有利于降低不良反应发生率,具有较高的安全性与有效性,在临床上的应用价值较高。Objective To investigate the clinical effect of amiodarone intravenous infusion in the treatment of acute heart failure with paroxysmal atrial fibrillation.Methods A total of 50 patients with acute heart failure and paroxysmal atrial fibrillation were randomly divided into control group and observation group,with 25 cases in each group.The control group was given conventional drug treatment,and the observation group was given amiodarone intravenous infusion on the basis of the control group.The therapeutic effect,cardiac function indicators[mean arterial pressure(MAP),heart rate(HR)],blood pressure(systolic blood pressure,diastolic blood pressure),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.00%,which was significantly higher than that of 76.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,MAP of(106.43±6.51)mm Hg(1 mm Hg=0.133 kPa)and HR of(80.04±4.23)times/min in the observation group were significantly lower than those of(121.86±10.24)mm Hg and(103.82±9.67)times/min in the control group,and the differences were statistically significant(P<0.05).After treatment,the diastolic blood pressure of(78.57±8.63)mm Hg and systolic blood pressure of(112.00±9.13)mm Hg in the observation group were significantly lower than those of(89.06±7.04)and(125.86±12.74)mm Hg in the control group,and the differences were statistically significant(P<0.05).The adverse reaction rate was 8.00%in the observation group,which was significantly lower than that of 32.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion In acute heart failure with paroxysmal atrial fibrillation,the amiodarone intravenous infusion can effectively improve the level of cardiac function and blood pressure of patients,which is conducive to reducing the incidence of adverse reactions,with high safety and effectiveness,and has high clinical application value.

关 键 词：胺碘酮 静脉滴注 急性心力衰竭 阵发性快速心房颤动 临床效果 

分 类 号：R541[医药卫生—心血管疾病]