二仙汤加减联合芬吗通治疗对原发性卵巢功能不全患者生殖内分泌激素及卵巢体积的影响  

Effect of modified Erxian Decoction combined with Femoston on the reproductive endocrine hormones and ovarian volume in patients with primary ovarian insufficiency

作　　者：魏少奔 王宇慧 武俊丽 孙晓盈 陈梦捷 WEI Shao-ben;WANG Yu-hui;WU Jun-li;SUN Xiao-ying;CHEN Meng-jie(Department of Gynecology,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710026,Shaanxi,CHINA;Department of Gynecology,Nanjing Hospital of Traditional Chinese Medicine,Nanjing 210001,Jiangsu,CHINA;Department of Gynecology,Yanta District Hospital of Traditional Chinese Medicine,Xi'an 710000,Shaanxi,CHINA;School of Medicine,Weinan Vocational and Technical College,Weinan 714000,Shaanxi,CHINA)

机构地区：[1]西安市中医医院妇科,陕西西安710026 [2]南京市中医院妇科,江苏南京210001 [3]西安市雁塔区中医医院妇科,陕西西安710000 [4]渭南职业技术学院医学院,陕西渭南714000

出　　处：《海南医学》2023年第15期2177-2180,共4页Hainan Medical Journal

基　　金：江苏省南京市中医院科研基金(编号:YJJ201907)。

摘　　要：目的探讨二仙汤加减联合芬吗通治疗对原发性卵巢功能不全(POI)患者生殖内分泌激素、卵巢体积的影响。方法选取2019年12月至2021年12月期间西安市中医医院妇科收治的122例POI患者为研究对象,按随机数表法分为研究组和对照组,每组61例,对照组患者采用芬吗通治疗,研究组患者采用二仙汤加减联合芬吗通治疗,两组均持续治疗3个周期,1个周期为28 d。比较两组患者治疗前后的血清促卵泡素(FSH)、雌二醇(E2)、促黄体生成素(LH)水平、子宫内膜厚度及绝经指数,并统计两组患者治疗后的不良反应发生情况。结果两组患者治疗后的FSH、LH和E2水平均得到不同程度改善,且研究组患者的FSH、LH水平分别为(12.07±4.42)U/L、(6.57±0.56)U/L,明显低于对照组的(19.35±3.98)U/L、(8.41±0.66)U/L,E2为(122.34±12.34)pmol/L,明显高于对照组的(91.65±13.75)pmol/L,差异均有统计学意义(P<0.05);两组患者治疗后的子宫内膜厚度均上升,绝经指数均下降,且研究组患者的子宫内膜厚度为(7.19±0.98)mm,明显厚于对照组的(6.11±0.81)mm,绝经指数为(9.19±1.24)分,明显低于对照组的(14.55±1.54)分,差异均有统计学意义(P<0.05);研究组不良反应总发生率为13.11%,略低于对照组的18.03%,但差异无统计学意义(P>0.05)。结论二仙汤加减联合芬吗通治疗POI可明显改善患者的卵巢体积和内分泌激素水平,且安全性高。Objective To analyze the effect of modified Erxian decoction combined with Femoston on the reproductive endocrine hormones and ovarian volume in patients with primary ovarian insufficiency(POI).Methods A total of 122 patients with POI admitted to the Department of Gynecology,Xi'an Hospital of Traditional Chinese Medicine from December 2019 to December 2021 were selected and randomly divided into a study group(n=61,treated with modified Erxian decoction combined with Femoston)and a control group(n=61,treated with Femoston).The treatment lasted for 3 cycles,with 28 days as one cycle.The serum levels of follicle-stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),endometrial thickness,and menopausal index before and after treatment were compared between the two groups.The incidence of adverse reactions after treatment was calculated.Results After treatment,FSH,LH,and E2 levels were improved to varying degrees in the two groups.FSH and LH in the study group were significantly lower than those in the control group:(12.07±4.42)U/L vs(19.35±3.98)U/L,(6.57±0.56)U/L vs(8.41±0.66)U/L,and E2 in the study group were significantly higher:(122.34±12.34)vs(91.65±13.75),with statistically significant differences(P<0.05).Endometrial thickness increased and menopause index decreased significantly in the two groups after treatment;endometrial thickness in the study group were significantly thicker than that in the control group:(7.19±0.98)mm vs(6.11±0.81)mm,and menopause index in the study group were significantly lower:(9.19±1.24)points vs(14.55±1.54)points,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the study group(13.11%)was slightly lower than that in the control group(18.03%),and there was no statistically significant difference between the two groups(P>0.05).Conclusion Modified Erxian decoction combined with Femoston can significantly improve the ovarian volume and endocrine hormone levels in POI patients,and has high safety.

关 键 词：原发性卵巢功能不全 二仙汤加减 芬吗通 生殖内分泌激素 卵巢体积 

分 类 号：R711.75[医药卫生—妇产科学]