有显著血流动力学影响的极低出生体质量早产儿动脉导管未闭手术疗效分析  

Surgical efficacy analysis of patent ductus arteriosus in very low birth weight preterm infants with significant hemodynamic effects

作　　者：施经添 何伦德 陈冬梅 王瑞泉 曾洪飚 SHI Jing-tian;HE Lun-de;CHEN Dong-mei;WANG Rui-quan;ZENG Hong-biao(Department of Pediatric Surgery,Quanzhou Children's Hospital,Fujian Medical University Teaching Hospital,Quanzhou 362000,Fujian,CHINA;Department of Neonatology,Quanzhou Children's Hospital,Fujian Medical University Teaching Hospital,Quanzhou 362000,Fujian,CHINA)

机构地区：[1]福建医科大学教学医院泉州市儿童医院小儿外科,福建泉州362000 [2]福建医科大学教学医院泉州市儿童医院新生儿科,福建泉州362000

出　　处：《海南医学》2023年第15期2229-2232,共4页Hainan Medical Journal

基　　金：福建省泉州市科技计划项目(编号:2019N048S)。

摘　　要：目的观察有显著血流动力学影响的极低出生体质量早产儿动脉导管未闭手术的临床效果。方法回顾性分析2019—2021年泉州市儿童医院收治的39例有显著血流动力学影响的极低出生体质量动脉导管未闭早产儿的临床资料,其中20例行动脉导管未闭结扎手术(手术组),19例未手术(非手术组),比较两组患儿的住院时间、机械通气时间、治愈出院率和主要并发症发生率。结果手术组患儿的治愈出院率为80.0%,明显高于未手术组的36.8%,差异有统计学意义(P<0.05);手术组患儿术后机械通气时间为(112.56±122.29)h,明显短于未手术组的(912.00±833.58)h,差异有统计学意义(P<0.05);手术组患儿的术后住院时间为(38.69±24.89)d,明显短于未手术组的(80.86±22.44)d,差异有统计学意义(P<0.05);手术组每例患儿的平均主要并发症数为(1.00±0.79)个,明显少于未手术组的(2.68±1.25)个,差异有统计学意义(P<0.05)。结论有显著血流动力学影响的极低出生体质量早产儿动脉导管未闭外科手术治疗为安全、有效的治疗手段,尽早手术治疗,能减少并发症,改善预后。Objective To observe the clinical effect of patent ductus arteriosus operation in very low birth weight preterm infants with significant hemodynamic effects.Methods The clinical data of 39 very low birth weight infants of patent ductus arteriosus with significant hemodynamic effects admitted to Quanzhou Children's Hospital from 2019 to 2021 were retrospective analyzed,including 20 undergoing patent ductus arteriosus ligation(operated group)and 19 not undergoing ligation(unoperated group).The two groups were compared in clinical indicators including length of hospital stay,mechanical ventilation time,number of major complications,cured and discharged rate.Results The cured and discharged rate of the operated group(80.0%)was significantly higher than that of the unoperated group(36.8%),P<0.05.Mechanical ventilation time of the operated group was(112.56±122.29)h,significantly shorter than(912.00±833.58)h in the unoperated group(P<0.05).The length of postoperative hospital stay in the operated group was(38.69±24.89)d,signifi cantly shorter than(80.86±22.44)d in the unoperated group(P<0.05).The average number of major complications per patient in the operated group was 1.00±0.79,significantly lower than 2.68±1.25 in the unoperated group(P<0.05).Conclusion Surgical treatment is a safe and effective treatment for very low birth weight infants of patent ductus arteriosus with significant hemodynamic effects.Early surgical treatment can reduce complications and improve prognosis.

关 键 词：极低出生体质量 早产儿 动脉导管未闭 外科手术 疗效 

分 类 号：R722[医药卫生—儿科]