猪圆环病毒3型与宿主相互作用机制研究进展  

Virus-host interaction:an overview on recent advances in porcine circovirus type 3

作　　者：孙仁杰 单颖 安慧婷[1] 王雅婷 谢荣辉 张传亮[1] 赵灵燕[1] 方维焕[2,3] 李肖梁 SUN Renjie;SHAN Ying;AN Huiting;WANG Yating;XIE Ronghui;ZHANG Chuanliang;ZHAO Ling-yan;FANG Weihuan;LI Xiaoliang(Zhejiang Provincial Center for Animal Disease Prevention&Control,Hangzhou 311199,China;Zhejiang Provincial Key Lab of Preventive Veterinary Medicine,Hangzhou 310058,China;College of Animal Sciences,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江省动物疫病预防控制中心,浙江杭州311199 [2]浙江省动物预防医学重点实验室,浙江杭州310058 [3]浙江大学动物科学学院,浙江杭州310058

出　　处：《浙江农业学报》2023年第7期1755-1762,共8页Acta Agriculturae Zhejiangensis

基　　金：浙江省自然科学基金(LQ23C180001);浙江省动物预防医学重点实验室开放基金(ZPKLPVM2022KFKT001);国家自然科学基金(32172819);浙江省“三农九方”科技协作项目(2022SNJF060,2023SNJF059)。

摘　　要：猪圆环病毒3型(porcine circovirus type 3,PCV3)从2015年发现至今已在全世界多个国家和地区的养猪业被检出,是重要的新发猪病病原体。目前有关PCV3致病机制的研究有限,大部分集中于PCV3的流行病学调查、基因组演化分析和检测方法建立。猪圆环病毒(porcine circovirus,PCV)与宿主之间关系紧密且复杂,二者的相互作用决定宿主细胞的命运和病毒的传播与存活。部分学者通过瞬转表达系统、临床分离和反向遗传学技术从病毒组分或全病毒水平对PCV3与宿主相互作用展开研究。本文系统阐述宿主细胞对PCV3感染的应答机制、PCV3-宿主蛋白的相互作用,以及PCV3生命周期的研究结果,将有助于进一步了解PCV3及其致病机制。Porcine circovirus type 3(PCV3)is an important emerging pathogen of swine disease,which has been reported in swine industry of several countries and regions since its discovery in 2015.Current understanding of PCV3 pathogenesis is limited.The majority of studies are focus on the retrospective investigation,genetic characterization,phylogenetic analysis and establishment of detection methods.PCVs-host relationship is close and complex,which involves various cellular and viral processes.The interaction between them determines cell fate and transmission and survival of PCVs.Recently,some researchers have conducted studies on the PCV3-host interaction at the virus component or whole virus level by utilizing transient expression system,clinical isolation and propagation and reverse genetics system.This review summarizes the recent progress on host response to viral infection,virus-host proteins interaction and viral life cycle,and could be helpful in understanding PCV3 pathogenesis.

关 键 词：猪圆环病毒3型 宿主响应 病毒生命周期 病毒与宿主互作 

分 类 号：S852.65[农业科学—基础兽医学]