干燥综合征患者唾液流率与口干症状的一致性分析  

Consistency of Salivary Flow Rate and Xerostomia in Patients with Sj gren's Syndrome

作　　者：卫明慧 汪苑苑 汪玉红 王新文 杜望磊 WEI Minghui;WANG Yuanyuan;WANG Yuhong;WANG Xinwen;DU Wanglei(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Clinical Research Center for Oral Diseases,Department of Oral medicine,School of Stomatology,the Fourth Military Medical University,Xi'an 710032,China;Department of Clinical Immunology,First Affiliated Hospital,the Fourth Military Medical University,Xi'an 710032,China)

机构地区：[1]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院口腔黏膜病科,陕西西安710032 [2]空军军医大学第一附属医院临床免疫科,陕西西安710032

出　　处：《口腔医学研究》2023年第8期751-754,共4页Journal of Oral Science Research

基　　金：空军军医大学第三附属医院新技术新业务(编号:LX-2020-403)。

摘　　要：目的:分析干燥综合征(Sjögren's syndrome,SS)患者口干症状与静息唾液流率下降的一致性,并探讨影响静息唾液流率的相关因素。方法:采集151例确诊SS患者的临床资料,包括口干症状、静息唾液流率、血液学指标及临床病史等,应用Kappa一致性检验和Spearman相关性检验进行统计学分析。结果:干燥综合征患者中唾液流率下降与口干症有极低的一致性,进一步分析发现,静息唾液流率下降与SS病程、ANA抗体滴度、IgM水平及自身免疫性肝病呈正相关关系。结论:SS患者唾液流率下降与口干症状缺乏一致表现,静息唾液流率虽然对SS有一定的预测及监控价值,但受到多种因素影响可能出现波动,了解其影响因素并实施定向干预,有助于SS患者的口腔健康管理。Objective:To assess the consistency of salivary flow rate and xerostomia,and explore the risk factors for reduced salivary flow rate in patients with Sjögren's syndrome(SS).Methods:The clinical data of 151 patients with SS were collected,including a sensation of oral dryness(xerostomia),unstimulated salivary flow rate(USFR),hematological indexes,and medical history.The Kappa consistency test and Spearman's correlation coefficient were used to analyze the data.Results:There was a very low consistency between the reduced USFR and xerostomia in SS patients.The reduced USFR was positively correlated with the course of SS,ANA antibody,IgM,and the comorbidity of autoimmune liver disease.Conclusion:The consistency of USFR and xerostomia in SS patients was poor.Although USFR has a certain predictive and monitoring value for SS,it may be influenced by multiple factors.Understanding the risk factors influencing USFR and implementing targeted intervention would be helpful for oral health management of SS patients.

关 键 词：干燥综合征 静息唾液流率 IgM 口干 自身免疫性肝病 SSA SSB 

分 类 号：R593.2[医药卫生—内科学]