Constructing bimodal nanoprobe based on Gd:AgInS_(2)/ZnS quantum dots for fluorometric/magnetic resonance imaging in mesenchymal stem cells  

作　　者：Dan Yang Xian Wei Zhiyan Piao Zhongjie Cui Haiyang He Zhuoqi Wen Wanlu Zhang Le Wang Shiliang Mei Ruiqian Guo 

机构地区：[1]Institute for Electric Light Sources,School of Information Science and Technology,Fudan University,Shanghai 200433,China [2]College of Electronic and Optical Engineering&College of Flexible Electronics,Nanjing University of Posts and Telecommunications,Nanjing 210023,China [3]Academy for Engineering and Technology,Fudan University,Shanghai 200433,China [4]Zhongshan-Fudan Joint Innovation Center,Zhongshan 528437,China [5]Yiwu Research Institute of Fudan University,Yiwu 322000,China

出　　处：《Journal of Materials Science & Technology》2023年第17期116-122,共7页材料科学技术（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(NSFC,No.62074044);the Zhongshan-Fudan Joint Innovation Center,and the Jihua Laboratory Projects of Guangdong Province(No.X190111UZ190).

摘　　要：Mesenchymal stem cells(MSCs)hold great promise in regenerative medicine and received overwhelm-ing concerns to promote their therapeutic effects.Owing to the shortage of MSCs-specific biomarkers,bimodal imaging nanoprobes with integrated complementary information are of great importance in ameliorating the efficacy of MSCs terminal tracking.In this study,a noninvasive dual-mode imaging nanoprobe with enhanced detection sensitivity and spatial resolution based on alloyed Gd:AgInS_(2)/ZnS quantum dots(QDs)was first fabricated through a microwave-assisted heating method.The QDs with red emissive fluorescence exhibit excellent biocompatibility in MSCs under a confocal microscope.As for magnetic resonance imaging(MRI),the longitudinal relaxation rate of 11.1420 mM^(-1) S^(-1) of Gd:AgInS_(2)/ZnS QDs was achieved,which was 1.7 times higher than that of commercial MRI contrast agent(6.4667 mM^(-1) S^(-1)).Furthermore,the cellular internalization of Gd:AgInS_(2)/ZnS QDs exerts no significant effect on the adipogenesis of MSCs and is conducive to the observation of further adipogenic differentiation.Our work helps to verify the promising prospect to develop a bimodal nanoprobe of fluorescence/MRI based on Gd:AgInS_(2)/ZnS QDs,which could monitor the differentiation and migration of MSCs for further therapeu-tic approach.

关 键 词：AgInS_(2)quantum dots Gd doping Dual-mode imaging Mesenchymal stem cells Differentiation 

分 类 号：R318[医药卫生—生物医学工程]