Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation,deep tumor penetration and augmented synergistic phototherapy  

作　　者：Wenjun Wang Enhui Ma Pengyu Tao Xiaoyu Zhou Yujuan Xing Liang Chen Yingying Zhang Jingjing Li Kai Xu Hong Wang Shaohui Zheng 

机构地区：[1]School of Medical Imaging,Xuzhou Medical University,Xuzhou 221006,China [2]School of Chemical Engineering&Technology,China University of Mining and Technology,Xuzhou 221116,China [3]Department of Radiology,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221004,China

出　　处：《Journal of Materials Science & Technology》2023年第17期171-185,共15页材料科学技术（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81901798,21905303,82172005);the Promotion Fund for Youth Talent of Jiangsu Association for Science and Technology(No.TJ-2021-069);the Startup Fund for Youth Talent in Xuzhou Medical University(No.D2019022);the Open Fund of Xuzhou Medical University(No.XYKF202102);the Fundamental Research Funds for the Central Universities(Nos.2020ZDPY0213,2022YCPY0205);the Natural Science Foundation of Jiangsu Province(Nos.BK20220161,BK20220663);the Jiangsu High-level Innovation and entrepreneurship Talent Project(No.RC5042001);the Jiangsu Province 6th“333 Project”of Cultivation of High-level Talents.

摘　　要：The complex tumor microenvironment(TME)with the characteristics of severe hypoxia,enriched hydro-gen peroxide(H_(2)O_(2))and dense nature significantly restricted the therapeutic efficacy of nanomedicine in cancer treatment.Synthetic micro/nanomotors have shown multiple versatility in modulating the abnor-mal TME and overcoming the limited penetration in solid tumor.Herein,we constructed a chemical-NIR dual-propelled nanomotor based on CuS/Pt Janus nanoparticles with IR820 encapsulation for hypoxia alle-viation,deep tumor penetration and augmented synergistic photodynamic(PDT)and photothermal ther-apy(PTT).The deposited Pt effectively catalyzed tumor endogenous H_(2)O_(2) into oxygen,which extremely relieved the tumor hypoxia state and allowed the chemical propulsion of nanomotors.Under NIR irra-diation,the Janus nanomotors exhibited more obvious movement via efficient photothermal conversion.Such autonomous motion significantly improved the tumoral accumulation of nanomotors and facilitated much deeper penetration inside tumor in vivo.In addition,enriched oxygen also promoted the genera-tion of reactive oxygen species(ROS)for augment of PDT,which achieved satisfied antitumor effect in combination with the PTT treatment.Therefore,this strategy based on CuS/Pt Janus nanomotors would provide an innovative dimension for considerable applications in effective cancer management.

关 键 词：CuS/Pt Janus nanomotors Chemical-NIR dual-propulsion Deep tumor penetration Hypoxia alleviation Synergistic PDT and PTT 

分 类 号：TG172[金属学及工艺—金属表面处理]