Advanced hemocompatible polyethersulfone composite artificial lung membrane with efficient CO_(2)/O_(2)exchange channel constructed by modified carbon nanotubes network  

作　　者：Yunbo Feng Qian Wang Shudong Sun Weifeng Zhao Changsheng Zhao 

机构地区：[1]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China [2]School of Chemical Engineering,Sichuan University,Chengdu 610065,China

出　　处：《Journal of Materials Science & Technology》2023年第29期181-193,共13页材料科学技术（英文版）

基　　金：the National Natural Science Foundation of China(Nos.U21A2098,51903171);the Key Research and Development Support Programme of Chengdu(No.2020-YF05-00316-SN);the State Key Research Development Pro-gramme of China(No.2018YFC1106400);the Science and Technol-ogy Project of Sichuan Province(No.2021YJ0188);the State Key Laboratory of Polymer Materials Engineering(No.sklpme2020-3-06).

摘　　要：Artificial lung membranes as the core module of the extracorporeal membrane oxygenation technology(ECMO)execute the function of extracorporeal blood-gas barrier accomplishing CO_(2)/O_(2)exchange with blood.However,the unsatisfactory hemocompatibility and difficulty in functionalization are the promi-nent challenges faced by current artificial lung membrane materials.In this study,polyethersulfone(PES)composite membranes with self-anticoagulant property and high gas exchange efficient are fabricated by blending PES matrix with poly(vinylamine)(PVAm)modified carboxylic carbon nanotubes(mCNTs)and citrate-based poly(octamethylene-citrate)(POC)pre-polymers.The mCNTs construct specific gas transfer channels within the composite membranes to enhance the gas permeability,while the POC pre-polymers provide anticoagulant property based on the chelation to blood Ca^(2+)and the inactivation effect to in-trinsic coagulation factors.Importantly,directed by the actual ECMO gas exchange mode,we design a gas-liquid convectional circulation device that could evaluate gas exchange efficiency for the composite membranes under mimetic ECMO state.Therefore,this strategy not only proposes a new design method of advanced artificial lung membranes to solve the practical challenges in the current ECMO technology,but also establishes a scientific testing method to evaluate the gas exchange performance for new-type artificial lung membrane materials in the future.

关 键 词：Composite membrane material Modified carbon nanotubes Artificial lung membranes Hemocompatibility Gas exchange 

分 类 号：TQ051.893[化学工程]