调脂汤联合泼尼松对肾病综合征患者糖脂代谢水平的影响  

Effects of Lipid-Regulating Decoction Combined with Prednisone on Glycolipid Metabolism Levels in Patients with Nephrotic Syndrome

作　　者：王淑娴 王敬斌 陈卫红 WANG Shu-xian;WANG Jing-bin;CHEN Wei-hong(Department of Nephrology,Ankang City Traditional Chinese Medicine Hospital,Ankang Shaanxi,725000)

机构地区：[1]安康市中医医院肾病科,陕西安康725000 [2]安康市中医医院治未病科,陕西安康725000

出　　处：《医学临床研究》2023年第7期1050-1053,共4页Journal of Clinical Research

摘　　要：【目的】探讨调脂汤联合泼尼松对肾病综合征(NS)患者糖脂代谢水平的影响。【方法】本院收治的98例NS患者,采用随机数字表法分为观察组和对照组,每组49例。对照组采用泼尼松治疗,观察组采用调脂汤联合泼尼松治疗,比较两组治疗后临床疗效、治疗前后中医症状评分、糖脂代谢水平、肾功能指标及两组不良反应发生情况。【结果】观察组患者总有效率为91.84%(45/49),明显高于对照组的77.55%(38/49)(P<0.05);观察组治疗后面浮肢肿、倦怠乏力、食少纳呆各项评分均低于治疗前及对照组治疗后(P<0.05);观察组治疗后空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)水平明显低于治疗前及对照组治疗后(P<0.05);观察组治疗后肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白定量低于治疗前及对照组治疗后(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】采用调脂汤联合泼尼松治疗NS患者,能明显降低患者中医症状评分,提高临床疗效,明显改善患者糖脂代谢水平及肾功能指标,且不良反应较少。【Objective】This study aimed to investigate the effects of lipid-regulating decoction combined with prednisone on the glycolipid metabolism levels in patients with nephrotic syndrome(NS).【Methods】A total of 98 patients with NS treated in our hospital were divided into an observation group and a control group by random number table method,with 49 patients in each group.The control group was treated with prednisone,while the observation group was treated with lipid-regulating decoction combined with prednisone.The clinical efficacy,traditional Chinese medicine symptom scores before and after treatment,levels of glycolipid metabolism,kidney function indicators,and the incidence of adverse reactions in the two groups were compared.【Results】The total effective rate in the observation group was 91.84%(45/49),significantly higher than 77.55%(38/49)in the control group(P<0.05).After treatment,the scores of facial and limb edema,fatigue,and anorexia of the observation group were all lower than those before treatment of the observation group and after treatment of the control group(P<0.05).After treatment,the levels of fasting blood glucose(FPG),triglycerides(TG),and total cholesterol(TC)in the observation group were significantly lower than those before treatment in the observation group and after treatment in the control group(P<0.05).After treatment,serum creatinine(Scr),blood urea nitrogen(BUN),and 24-hour urinary protein quantification in the observation group were lower than those before treatment and after treatment in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】The treatment of NS patients with lipid-regulating decoction combined with prednisone can significantly reduce the traditional Chinese medicine symptom scores,improve clinical efficacy,and significantly improve glycolipid metabolism levels and kidney function indicators with minimal adverse reactions.

关 键 词：肾病综合征/中西医结合疗法 泼尼松/治疗应用 糖脂类/代谢 

分 类 号：R692[医药卫生—泌尿科学]