adipsin、A-FABP在妊娠期糖尿病胰岛素抵抗患者血清中的表达水平及其临床意义  

Expression and Clinical Significance of Adipsin and A-FABP in Serum of Pregnant Diabetes Patients with Insulin Resistance

作　　者：连荣丽 张忍萍 LIAN Rong-li;ZHANG Ren-ping(Department of Obstetrics and Gynecology,Ankang Maternal and Child Health Hospital,Ankang Shaanxi 725000)

机构地区：[1]陕西省安康市妇幼保健院妇保科,陕西安康725000 [2]陕西省汉阴县妇幼保健院妇产科,陕西安康725109

出　　处：《医学临床研究》2023年第7期1070-1073,共4页Journal of Clinical Research

摘　　要：【目的】探讨脂肪酶(adipsin)、脂肪细胞脂肪酸结合蛋白(A-FABP)在妊娠期糖尿病(GDM)胰岛素抵抗患者血清中的表达水平及其临床意义。【方法】选取陕西省安康市妇幼保健院2019年6月至2022年6月收治的100例GDM患者(观察组),另外,选取同期100例产检正常的孕妇作为对照组。比较两组孕妇三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、稳态模型胰岛素抵抗指数(HOMA-IR)、adipsin、A-FABP水平;采用Spearman相关系数模型分析糖脂代谢指标、adipsin、A-FABP与HOMA-IR的相关性;采用非条件Logistic逐步回归分析GDM患者发生胰岛素抵抗的影响因素。【结果】观察组TG、FPG、HbAlc、FINS、HOMA-IR、adipsin、A-FABP水平均显著高于对照组(P>0.05);但两组TC、HDL-C、LDL-C比较,差异无统计学意义(P>0.05);相关性分析结果显示:FPG、HbAlc、FINS、TG、adipsin、A-FABP与HOMA-IR呈正相关(P<0.05);多因素Logistic回归性分析结果显示:FPG、HbAlc、FINS、TG、adipsin、A-FABP是GDM患者发生胰岛素抵抗的影响因素(P<0.05)。【结论】adipsin、A-FABP与GDM胰岛素抵抗显著相关,是预测GDM胰岛素抵抗的重要指标。【Objective】To investigate the expression and clinical significance of lipase(adipsin)and adipocyte fatty acid binding protein(A-FABP)in the serum of patients with insulin resistance in gestational diabetes(GDM).【Method】A total of 100 GDM patients admitted to Ankang Maternal and Child Health Hospital from June 2019 to June 2022 were selected as the observation group,while 100 healthy pregnant women with normal prenatal examination in the same period were selected as the control group.The levels of triglyceride(TG),total cholesterol(TC),High-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FPG),fasting insulin(FINS),glycosylated hemoglobin(HbA1c),homeostasis model insulin resistance index(HOMA-IR),adipsin,and A-FABP were compared between the two groups of pregnant women.The Spearman correlation coefficient model was used to analyze the relationship among the indexes of glycolipid metabolism,adipsin,A-FABP and HOMA-IR.The correlation between A-FABP and HOMA-IR was analyzed using unconditional logistic stepwise regression to determine the influencing factors of insulin resistance in GDM patients.【Result】The TG,FPG,HbAlc,FINS,HOMA-IR,adiposin and A-FABP of the observation group were significantly higher than those of the control group(P<0.05).However,there were no statistically significant differences in TC,HDL-C,and LDL-C between the two groups(P>0.05).The correlation analysis showed that a positive correlation with HOMA-IR with levels of FPG,HbAlc,FINS,TG,adiposin,and A-FABP showed(P<0.05).The results of multivariate logistic regression analysis showed that FPG,HbAlc,FINS,TG,adiposin,and A-FABP were the influencing factors for insulin resistance in GDM patients(P<0.05).【Conclusion】Adipsin and A-FABP are significantly correlated with GDM insulin resistance and they are important indicators for predicting GDM insulin resistance.

关 键 词：糖尿病 妊娠 胰岛素抵抗 补体因子D 脂肪酸结合蛋白质类 

分 类 号：R714.2[医药卫生—妇产科学]