湖州市老年人接种流感灭活疫苗疑似预防接种异常反应监测结果  

Surveillance of adverse events following immunization with inactivated influenza vaccines among the elderly in Huzhou City

作　　者：张超 罗小福[1] 刘艳 沈建勇[1] 徐秦儿[1] 韩利萍 马力[1] ZHANG Chao;LUO Xiaofu;LIU Yan;SHEN Jianyong;XU Qin'er;HAN Liping;MA Li(Department of Immunization Planning,Huzhou Center for Disease Control and Prevention,Huzhou,Zhejiang 313000,China)

机构地区：[1]湖州市疾病预防控制中心免疫规划科,浙江湖州313000

出　　处：《预防医学》2023年第8期701-704,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：湖州市疾病预防控制中心科技计划项目(KJJH202208);湖州市疾病预防控制中心急性传染病学重点学科(ZDXK202202)。

摘　　要：目的了解浙江省湖州市老年人接种流感灭活疫苗(IIV)疑似预防接种异常反应(AEFI),为IIV安全性监测和评价提供依据。方法通过中国疾病预防控制信息系统免疫规划系统AEFI监测模块收集2020—2022年湖州市≥60岁老年人IIV接种后的AEFI监测资料,包括人口学信息、AEFI发生时间、AEFI分类和临床症状等;采用描述性流行病学方法分析AEFI报告发生率及流行特征。结果2020—2022年湖州市≥60岁老年人IIV接种后报告AEFI 84例,报告发生率为9.83/10万剂,其中三价流感灭活疫苗(IIV3)和四价流感灭活疫苗(IIV4)报告发生率分别为9.74/10万剂和48.71/10万剂。一般反应、异常反应、偶合症和心因性反应报告发生率分别为7.96/10万剂、1.52/10万剂、0.23/10万剂和0.12/10万剂,无疫苗质量事故和接种差错事故报告。AEFI病例中,女性52例,男性32例;年龄以60~<70岁为主,44例占52.38%。南浔区报告发生率较高,为17.94/10万剂。接种后24 h内发生AEFI 79例,占94.05%。临床症状以发热、局部红肿和局部硬结为主,报告发生率分别为2.22/10万剂、3.74/10万剂和1.99/10万剂。结论湖州市≥60岁老年人接种IIV后AEFI报告发生率较低,以一般反应为主,多数发生在接种后24 h内。Objective To investigate the incidence of adverse events following immunization(AEFI)with inactivated influenza vaccine among the elderly in Huzhou City,Zhejiang Province,so as to provide insights into safety monitoring and evaluation of inactivated influenza vaccines.Methods Data pertaining to surveillance on AEFI with inactivated influenza vaccines among the elderly at ages of 60 years and older in Huzhou City from 2020 to 2022 were collected from the AEFI Monitoring Information Management System of the Immunization Planning System of Chinese Disease Control and Prevention Information System,including demographics,time of AEFI occurrence,classification of AEFI and clinical syndromes,and the reported incidence and epidemiological features of AEFI with inactivated influenza vaccines were analyzed using a descriptive epidemiological method.Results Totally 84 elderly cases at ages of 60 years and older were reported with AEFI with inactivated influenza vaccines in Huzhou City from 2020 to 2022,with a reported incidence rate of 9.83/105 doses,and the reported incidence rates of AEFI with trivalent and quadrivalent inactivated influenza vaccines were 9.74/105 doses and 48.71/105 doses,respectively.The reported incidence rates of general,abnormal,coincidence and psychogenic reactions were 7.96/105 doses,1.52/105 doses,0.23/105 doses and 0.12/105 doses,respectively,and no vaccine quality accidents or wrong vaccine administered were reported.The cases with AEFI included 52 women and 32 men,and most cases were aged from 60 to 69 years(44 cases,52.38%).The highest incidence of AEFI was reported in Nanxun District(17.94/105 doses),and there were 79 cases(94.05%)with AEFI within 24 hours following vaccination.The clinical symptoms mainly included fever,local redness and swelling,and local induration,with reported incidence rates of 2.22/105 doses,3.74/105 doses,and 1.99/105 doses,respectively.Conclusions The reported incidence of AEFI with inactivated influenza vaccines is low among the elderly at ages of 60 years and older

关 键 词：流感疫苗 疑似预防接种异常反应 监测 疫苗安全性 

分 类 号：R186[医药卫生—流行病学]