基于分数低频振幅与功能连接性的湿疹瘙痒症脑影像学特征分析  

Cerebral imaging characteristics of pruritus caused by eczema based on fALFF and FC analyses

作　　者：张钰莹 金兑垠 徐慧慧 沈嫱 王辉[1] 谭文莉[1] 龚志刚[1] 詹松华[1] 魏翔宇 ZHANG Yuying;KIM Taeeun;XU Huihui;SHEN Qiang;WANG Hui;TAN Wenli;GONG Zhigang;ZHAN Songhua;WEI Xiangyu(Department of Radiology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Acupuncture&Moxibustion,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Acupuncture and Anesthesia,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院放射科,上海201203 [2]上海中医药大学附属曙光医院针灸科,上海201203 [3]上海中医药大学附属曙光医院针刺麻醉研究所,上海201203

出　　处：《磁共振成像》2023年第8期45-50,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:82205267)。

摘　　要：目的采用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)技术,分析瘙痒患者的脑影像学特征。材料与方法选取42名湿疹患者纳入观察组,44名健康受试者纳入对照组。观察组记录瘙痒视觉模拟评分法(VisualAnalogueScale,VAS)评分、12项瘙痒严重程度评估量表(12-ItemPruritusSeverityScale,12-PSS)、湿疹面积及严重程度评分、匹兹堡睡眠质量指数、焦虑自评量表。所有受试者在rs-fMRI扫描后,首先比较分数低频振幅(fraction amplitude of low frequency fluctuation,fALFF)值有差异的脑区,随后以差异脑区为种子点进行全脑功能连接性(functional connectivity,FC)分析。结果两组年龄、性别构成比、受教育年限等基本资料差异无统计学意义(P>0.05)。与对照组相比,观察组左侧中央前回、左侧中央后回、左侧补充运动区、左侧中扣带回的fALFF值增高。观察组左侧中央前回与双侧颞下回、双侧梭状回、双侧海马、双侧颞中回、双侧枕下回、双侧舌回之间的FC值减低;左侧补充运动区与双侧颞下回、双侧颞上回、右侧海马、右侧脑岛的FC值减低。观察组12-PSS评分和左侧中央前回(r=0.59,P<0.01)、左侧中央后回的fALFF值呈正相关(r=0.52,P<0.01),和VAS评分呈正相关(r=0.33,P<0.05)。结论瘙痒患者左侧躯体感觉运动区自发活性异常增高且部分脑区和瘙痒量表之间存在相关性,为今后研究瘙痒提供了潜在的神经生物学标记物;左侧躯体感觉运动区和枕叶、颞叶部分脑区之间的FC同步下降是瘙痒患者另一重要的脑网络特征。Objective:To analyze the cerebral characteristics of patients with pruritus by resting-state functional magnetic resonance imaging(rs-fMRI).Materials and Methods:Forty-two patients with eczema were recruited in the observation group,and 44 healthy subjects were included in the control group.The visual analogue scale(VAS),12-Item Pruritus Severity Scale(12-PSS),Pittsburgh Sleep Quality Index and Self-rating Anxiety Scale were recorded in the observation group.The different values of fraction amplitude of low frequency fluctuation(fALFF)were compared between the observation and control group through rs-fMRI program.Subsequently,functional connectivity(FC)was analyzed using the brain regions with significant differences between groups as seed points.Results:There were no significant differences in average age,sex ratio,years of education between the two groups(P>0.05).Compared with the control group,the fALFF values of the left precentral gyrus,left postcentral gyrus,left supplementary motor area,and left anterior cingulate cortex in the observation group were increased.The FC values between the left precentral gyrus and bilateral inferior temporal gyrus,bilateral fusiform gyrus,bilateral hippocampus,bilateral middle temporal gyrus,bilateral inferior occipital gyrus,and bilateral lingual gyrus were decreased in the observation group.The FC values between left supplementary motor area and bilateral inferior temporal gyrus,bilateral superior temporal gyrus,right hippocampus and right insula were decreased in the observation group.The 12-PSS score was positively correlated with fALFF value of left precentral gyrus(r=0.59,P<0.01)and left postcentral gyrus(r=0.52,P<0.01),and was positively correlated with VAS score(r=0.33,P<0.05)in the observation group.Conclusions:The spontaneous activity of the left somatosensory and motor area are abnormally increased in patients with pruritus,and there is a correlation between given cerebral regions and clinical scales,which provides potential neurobiological markers for the future s

关 键 词：皮肤病 湿疹 瘙痒 中枢机制 分数低频振幅 功能连接性 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R751[医药卫生—诊断学]