超顺磁性氧化铁纳米粒子在肿瘤诊断及治疗方面的应用  

Application of superparamagnetic iron oxide nanoparticle in the diagnosis and treatment of tumor

作　　者：左柔柔 陈柏青 孙洪赞[1] ZUO Rourou;CHEN Baiqing;SUN Hongzan(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Nuclear Medicine,People's Hospital of Liaoning Provincial,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院放射科,沈阳110004 [2]辽宁省人民医院核医学科,沈阳110000

出　　处：《磁共振成像》2023年第8期197-202,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:82171910)。

摘　　要：超顺磁性氧化铁纳米粒子(superparamagnetic iron oxide nanoparticle, SPION)由于其独特的性质,如低毒、生物相容性、强大的磁性,以及在多功能模式中的优越作用,在肿瘤诊断、构建多模态肿瘤分子影像探针及治疗方面展现出巨大的潜力,今后可以在临床上提高肿瘤诊断的特异性、敏感性,实现诊疗一体化,本文从SPION的成像机制、合成方法出发,阐述近年来SPION在肿瘤的各种靶向成像、多模态成像和治疗方面的研究进展,展望未来SPION在肿瘤诊断及治疗中的发展前景,旨在为更好地构建基于SPION的新型诊疗一体化肿瘤探针提供参考。Superparamagnetic iron oxide nanoparticle(SPION)show great potential in tumor diagnosis,construction of multimodal tumor molecular imaging probes and treatment because of their unique properties,such as low toxicity,biocompatibility,strong magnetism and superior role in multi-functional mode.In the future,it can improve the specificity and sensitivity of tumor diagnosis and realize the integration of diagnosis and treatment.Based on the imaging mechanism and synthesis methods of SPION,we described some research progress of SPION in various targeted imaging,multimodal imaging and treatment of tumors in recent years,and looked forward to the future development prospect of SPION in tumor diagnosis and treatment in this paper,in order to better construct a new type of integrated tumor probe based on SPION in the future.

关 键 词：肿瘤 超顺磁性氧化铁纳米粒子 诊断 治疗 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R73[医药卫生—诊断学]