High Arterial Oxygen Saturation in the Acclimatized Lowlanders Living at High Altitude  

作　　者：Yaoxi He Chaoying Cui Yongbo Guo Wangshan Zheng Tian Yue Hui Zhang Ouzhuluobu Tianyi Wu Xuebin Qi Bing Su 

机构地区：[1]State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China [2]High Altitude Medical Research Center,School of Medicine,Tibetan University,Lhasa 850000,China [3]National Key Laboratory of High Altitude Medicine,High Altitude Medical Research Institute,Xining 810012,China

出　　处：《Phenomics》2023年第4期329-332,共4页表型组学（英文）

基　　金：Funding This study was funded by grants from the National Natural Science Foundation of China(NSFC)(32288101 and 91631306 to BS;3217040584 and 32000390 to YH,32070578 and U22A20340 to XQ,and 32170629 to HZ);the Youth Innovation Promotion Association of CAS(to YH);the Science and Technology General Program of Yunnan Province(202301AW070010 and 202001AT070110 to YH);the Provincial Key Research,Development and Translational Program of Tibetan Autonomous Region of China(XZ202201ZY0035G to XQ);the State Key Laboratory of Genetic Resources and Evolution(GREKF22-15 to HZ).

摘　　要：Blood oxygen saturation(SpO_(2))is a key indicator of oxygen availability in the body.It is known that a low SpO_(2)at high altitude is associated with morbidity and mortality risks due to physiological hypoxemia.Previously,it was proposed that the lowlander immigrants living at high altitude should have a lower SpO_(2)level compared to the highlander natives,but this proposal has not been rigorously tested due to the lack of data from the lowlander immigrants living at high altitude.In this study,we compared arterial oxygen saturation of 5929 Tibetan natives and 1034 Han Chinese immigrants living at altitudes ranging from 1120 m to 5020 m.Unexpectedly,the Han immigrants had a higher SpO_(2)than the Tibetan natives at the same high altitudes.At the same time,there is a higher prevalence of chronic mountain sickness in Han than in Tibetans at the same altitude.This result suggests that the relatively higher SpO_(2)level of the acclimatized Han is associated with a physiological cost,and the SpO_(2)level of Tibetans tends to be sub-optimal.Consequently,SpO_(2)alone is not a robust indicator of physiological performance at high altitude.

关 键 词：Oxygen saturation High altitude ACCLIMATIZATION ADAPTATION 

分 类 号：R56[医药卫生—呼吸系统]