Advances in probing single biomolecules: From DNA bases to glycans  

作　　者：Baofei Hou Teng Zhang Huixia Yang Xu Han Liwei Liu Linfei Li Cesare Grazioli Xu Wu Nan Jiang Yeliang Wang 

机构地区：[1]MIIT Key Laboratory for Low-Dimensional Quantum Structure and Devices,School of Integrated Circuits and Electronics,Beijing Institute of Technology,Beijing,China [2]Department of Chemistry,University of Illinois Chicago,Chicago,Illinois,USA [3]IOM-CNR,Istituto Officina dei Materiali,Trieste,Italy

出　　处：《Interdisciplinary Materials》2023年第4期511-528,共18页交叉学科材料（英文）

基　　金：support of the Beijing Natural Science Foundation(Nos.Z190006 and 4192054);National Key Research and Development Program of China(Nos.2019YFA0308000,2020YFA0308800,and 2021YFA1400100);National Natural Science Foundation of China(Nos.92163206,61971035,61725107,and 62271048);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB30000000).

摘　　要：Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level.Among the various imaging techniques available for biomolecules and their assembled nanostructures,scanning probe microscopy(SPM)provides a powerful and nondestructive imaging option.SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale(e.g.,glycans).This review highlights recent achievements in studying biomolecules using SPM technique,focusing on DNA bases,amino acids,proteins,and glycans.The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property relationship.High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

关 键 词：atomic-scale probing biomolecules scanning probe microscopy structure VISUALIZATION 

分 类 号：TH742[机械工程—光学工程]