Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine  

作　　者：Filipe V.Ferreira Alana G.Souza Rubina Ajdary Lucas P.de Souza Jo˜ao H.Lopes Daniel S.Correa Gilberto Siqueira Hernane S.Barud Derval dos S.Rosa Luiz H.C.Mattoso Orlando J.Rojas 

机构地区：[1]Nanotechnology National Laboratory for Agriculture(LNNA),Embrapa Instrumentation-Rua XV de Novembro,1452,S˜ao Carlos,SP,13560-979,Brazil [2]Center for Engineering,Modeling,and Applied Social Sciences(CECS),Federal University of ABC(UFABC),Santo Andr´e,Brazil [3]Department of Bioproducts and Biosystems,School of Chemical Engineering,Aalto University,P.O.Box 16300,Aalto,Espoo,FIN-00076,Finland [4]College of Engineering and Physical Sciences,Aston Institute of Materials Research,Aston University,Birmingham,UK [5]Department of Chemistry,Division of Fundamental Sciences(IEF),Technological Institute of Aeronautics(ITA),S˜ao Jose dos Campos,SP,Brazil [6]Laboratory for Cellulose&Wood Materials,Empa-Swiss Federal Laboratories for Materials Science and Technology,Überlandstrasse 129,8600,Dübendorf,Switzerland [7]Biopolymers and Biomaterials Laboratory(BIOPOLMAT),University of Araraquara(UNIARA),Araraquar1,14801-340,S˜ao Paulo,Brazil [8]Bioproducts Institute,Department of Chemical&Biological Engineering,Department of Chemistry and,Department of Wood Science,The University of British Columbi1,2360 East Mall,Vancouver,BC,V6T 1Z3,Canada

出　　处：《Bioactive Materials》2023年第11期151-176,共26页生物活性材料（英文）

基　　金：the S˜ao Paulo Research Foundation[FAPESP;Grants No.2016/10636-8,2020/07956-6,2018/22214-6,2022/03247-6];the Brazilian National Council for Scientific and Technological Development[CNPq;Grants No 001];the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program[ERC Advanced Grant Agreement No.788489,“BioElCell”];the Canada Excellence Research Chair Program[CERC-2018-00006];Canada Foundation for Innovation[Project number 38623].

摘　　要：We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关 键 词：Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial Sustainable materials Green nanomaterials 

分 类 号：TB3[一般工业技术—材料科学与工程]