穴位贴敷联合补肾活血法对复发性流产病人外周血中抗β2糖蛋白Ⅰ抗体、血小板功能的有效性分析  

Effectiveness analysis of acupoint application combined with kidney tonification and blood activation method on anti-β2 glycoproteinⅠantibody and platelet function in patients with recurrent abortion

作　　者：杨洁[1] 毕亚菊 梁志超[1] YANG Jie;BI Ya-ju;LIANG Zhi-chao(Department of Gynecology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050000,China)

机构地区：[1]河北省石家庄市中医院妇科,050000

出　　处：《蚌埠医学院学报》2023年第7期932-936,共5页Journal of Bengbu Medical College

基　　金：河北省中医药管理局科研计划项目(2019445)。

摘　　要：目的:探究穴位贴敷联合补肾活血法对复发性流产病人的有效性分析。方法:选取复发性流产病人90例,将其随机分为西药组(A组)、西药+中药组(B组)、西药+中医综合治疗组(C组),每组30例。A组:口服阿司匹林;B组:口服阿司匹林同时给予补肾活血中药;C组在B组的基础上应用穴位贴敷;均至孕12周。观察3组病人治疗前后临床疗效、血清人绒毛促性腺激素(hCG)、孕酮(P)、抗心磷脂抗体(ACA)、抗β2糖蛋白Ⅰ抗体(Anti-β2-GPⅠ)及B超情况等。结果:治疗后,3组疗效差异有统计学意义(P<0.05);C组疗效高于A、B组(P<0.05~P<0.01)。治疗后,3组病人hCG与P较同组治疗前明显升高(P<0.01),C组明显高于A、B组(P<0.01)。治疗后,B、C组病人ACA及Anti-β2-GPI阳性率均较同组治疗前降低(P<0.05),A组与治疗前比较降低程度差异无统计学意义(P>0.05)。治疗后,3组ACA和Anti-β2-GPI阳性率比较,差异均有统计学意义(P>0.05),其中C组低于A组和B组(P<0.05)。治疗后,3组血小板功能均有所改善,D-二聚体(D-D)水平明显低于治疗前(P<0.01),C组D-D水平明显低于A、B组(P<0.01),B组明显低于A组(P<0.01)。结论:穴位贴敷联合补肾活血法对复发性流产病人治疗具有显著疗效,可有效改善病人激素水平及血小板功能,提高病人治愈率,值得在临床应用。Objective:To investigate the effectiveness analysis of acupoint application combined with kidney tonification and blood activation method on patients with recurrent abortion.Methods:A total of 90 patients with recurrent abortion were selected and randomly divided into western medicine group(group A),western medicine+triditional Chinese medicine group(group B)and western medicine+Chinese medicine comprehensive treatment group(group C),with 30 patients in each group.Group A:oral aspirin;group B:oral aspirin and triditional Chinese medicine for kidney tonification and blood activation;group C:acupoint application on the basis of group B;all until 12 weeks of pregnancy.The clinical efficacy,serum human chorionic gonadotropin(hCG),progesterone(P),anti-cardiolipin antibody(ACA),anti-β2-glycoproteinⅠantibody(anti-β2-GPⅠ)and ultrasound were observed before and after treatment in the three groups.Results:After treatment,the differences were statistically significant in the efficacy of the three groups(P<0.05),and the efficacy of group C was higher than that of group A and group B(P<0.05 to P<0.01).The hCG and P were significantly higher in patients of the three groups compared with the same group before treatment(P<0.01),and group C was significantly higher than group A and group B(P<0.01).The positive rates of ACA and anti-β2-GPⅠin group B and group C were lower than those before treatment in the same group(P<0.05),and the difference between the degree of reduction in group A and before treatment was not statistically significant(P>0.05).The positive rates of ACA and anti-β2-GPⅠbetween the three groups were statistically significant(P>0.05),among which,group C was lower than group A and group B(P<0.05).The platelet function improved in all groups,the(D-D)levels were significantly lower than before treatment(P<0.01),the D-D levels in group C were significantly lower than those in group A and group B(P<0.01),and group B was significantly lower than group A(P<0.01).Conclusions:Acupoint application combined with

关 键 词：复发性流产 穴位贴敷 补肾活血法 血小板功能 抗β2糖蛋白Ⅰ抗体 

分 类 号：R714[医药卫生—妇产科学]